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AT-007

Catalog No. T10393 CAS 2170729-29-8

AT-007 is an orally active CNS penetrant Aldose <a href="/target/Reductase" style="display: inline; color: #c13a36">Reductase</a> inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

AT-007, CAS 2170729-29-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 76.00
5 mg	In stock	$ 157.00
10 mg	In stock	$ 244.00
25 mg	In stock	$ 441.00
50 mg	In stock	$ 722.00
100 mg	In stock	$ 994.00
200 mg	In stock	$ 1,491.00
1 mL * 10 mM (in DMSO)	In stock	$ 167.00

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Purity: 99.36%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.
Targets&IC50	Aldose reductase:100 pM
In vivo	AT-007 significantly reduces galactitol levels in GALT null rats in all target tissues ( liver, brain, and plasma), and does not increase galactose or Gal-1P levels [2].

Molecular Weight	425.41
Formula	C17H10F3N3O3S2
CAS No.	2170729-29-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 35.71 mg/mL (83.94 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Maeve Conneighton, et al. Applied Therapeutics Announces Initiation of Phase 1/2 Study of AT-007 in Galactosemia. 2. UNITED STATES SECURITIES AND EXCHANGE COMMISSION. APPLIED THERAPEUTICS, INC.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max NO PAINS Compound Library Drug Repurposing Compound Library Clinical Compound Library Bioactive Compound Library Inhibitor Library Endocrinology-Hormone Compound Library Orally Active Compound Library Metabolism Compound Library Pediatric Drug Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AT-007 2170729-29-8 Endocrinology/Hormones Metabolism Reductase inhibit AT 007 Aldose Reductase AT007 Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.