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AT-007

Catalog No. T10393   CAS 2170729-29-8

AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.

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AT-007 Chemical Structure
AT-007, CAS 2170729-29-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 73.00
5 mg In stock $ 158.00
10 mg In stock $ 249.00
25 mg In stock $ 463.00
50 mg In stock $ 683.00
100 mg In stock $ 973.00
1 mL * 10 mM (in DMSO) In stock $ 173.00
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Purity: 99.36%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.
Targets&IC50 Aldose reductase:100 pM
In vivo AT-007 markedly reduces galactitol levels across all target tissues (liver, brain, and plasma) in GALT null rats, without elevating galactose or Gal-1P concentrations [2].
Molecular Weight 425.4
Formula C17H10F3N3O3S2
CAS No. 2170729-29-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 35.71 mg/mL (83.94 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Maeve Conneighton, et al. Applied Therapeutics Announces Initiation of Phase 1/2 Study of AT-007 in Galactosemia. 2. UNITED STATES SECURITIES AND EXCHANGE COMMISSION. APPLIED THERAPEUTICS, INC.

Related compound libraries

This product is contained In the following compound libraries:
Drug Repurposing Compound Library Inhibitor Library Pediatric Drug Library NO PAINS Compound Library Bioactive Compound Library Metabolism Compound Library Bioactive Compounds Library Max Orally Active Compound Library Endocrinology-Hormone Compound Library Clinical Compound Library

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Keywords

AT-007 2170729-29-8 Endocrinology/Hormones Metabolism Reductase inhibit Aldose Reductase Inhibitor AT 007 AT007 inhibitor

 

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