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Uridine triacetate

Catalog No. T21327 CAS 4105-38-8

Synonyms: RG 2133 triacetate, PN-401, Tri-O-acetyluridine, PN401, RG 2133, RG-2133, PN 401, RG2133, RG2133 triacetate

Uridine triacetate (RG 2133 triacetate) (Tri-O-acetyl uridine), an orally active prodrug of uridine, is efficiently absorbed in the gut and swiftly deacetylated in the circulation to release free uridine. It is utilized in the research of 5-fluorouracil (5-FU) and capecitabine toxicity, particularly targeting early-onset cardiac or central nervous system (CNS) complications.

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Uridine triacetate, CAS 4105-38-8

Pack Size	Availability	Price/USD
50 mg	In stock	$ 30.00
100 mg	In stock	$ 39.00
200 mg	In stock	$ 55.00
500 mg	In stock	$ 91.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.94%

Biological Description

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Storage & Solubility Information

Description	Uridine triacetate (RG 2133 triacetate) (Tri-O-acetyl uridine), an orally active prodrug of uridine, is efficiently absorbed in the gut and swiftly deacetylated in the circulation to release free uridine. It is utilized in the research of 5-fluorouracil (5-FU) and capecitabine toxicity, particularly targeting early-onset cardiac or central nervous system (CNS) complications.
In vitro	Uridine triacetate inhibits [3H]uridine uptake in ENT1 and ENT2 overexpressed HeLa cells, with IC50s of 28.4 μM and 228.4 μM respectively[4].
In vivo	Uridine triacetate (2 g/kg, oral gavage, every 8 h for 15 total doses) improves survival and reduced toxicity in 5-FU overdose mice. Uridine triacetate (2 g/kg, oral gavage, every 8 h for 15 total doses) improves survival and reduced 5-FU toxicity in DPD deficiency mice[3].

Synonyms	RG 2133 triacetate, PN-401, Tri-O-acetyluridine, PN401, RG 2133, RG-2133, PN 401, RG2133, RG2133 triacetate
Molecular Weight	370.31
Formula	C15H18N2O9
CAS No.	4105-38-8

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 90mg/mL (243mM)

References and Literature

1. Ma WW, et al. Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Cancer. 2017 Jan 1;123(2):345-356. 2. Cada DJ, et al. Uridine Triacetate. Hosp Pharm. 2016 Jun;51(6):484-8. 3. Rolando A G Garcia, et al. Prompt treatment with uridine triacetate improves survival and reduces toxicity due to fluorouracil and capecitabine overdose or dihydropyrimidine dehydrogenase deficiency. Toxicol Appl Pharmacol. 2018 Aug 15;353:67-73. 4. Siennah R Miller, et al. Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling. Mol Pharmacol. 2021 Feb;99(2):147-162.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library ReFRAME Related Library Bioactive Compounds Library Max FDA-Approved Drug Library Anti-Cancer Compound Library Clinical Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Uridine triacetate 4105-38-8 Others RG 2133 triacetate PN-401 Tri-O-acetyluridine PN401 RG 2133 Triacetate RG 2133 Uridine Triacetate RG2133 Triacetate Uridine RG-2133 Triacetate RG-2133 PN 401 RG2133 RG2133 triacetate inhibitor inhibit

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