Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.4 microM and has inhibitory effects of sorbitol accumulation, suggests that it is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 72.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 413.00 | |
25 mg | In stock | $ 828.00 | |
50 mg | In stock | $ 1,120.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 258.00 |
Description | Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.4 microM and has inhibitory effects of sorbitol accumulation, suggests that it is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications. |
In vitro | The inhibitory effects of compounds from Salicornia herbacea (Chenopodiaceae) on rat lens aldose reductase (RLAR) and sorbitol accumulation in streptozotocin-induced diabetic rat tissues were investigated. METHODS AND RESULTS:The various fractions from the MeOH extract of S. herbacea were tested for their effects on RLAR in vitro. Among them, the EtOAc fraction was found to exhibit a potent RLAR inhibition (IC(50)=0.75 microg/ml), from which an active principle as a potent AR inhibitor was isolated and its chemical structure was elucidated as Isorhamnetin-3-O-beta-D-Glucoside (1) by spectral analysis. Compound 1 exhibited a potent RLAR inhibition in vitro, its IC(50) being 1.4 microM. Compound 1, when administered orally at 25 mg/kg in streptozotocin (STZ)-induced diabetic rats, caused not only a significant inhibition of serum glucose concentration but also sorbitol accumulation in the lenses, red blood cells (RBC), and sciatic nerves. CONCLUSIONS:These results indicate that compound 1 from S. herbacea is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications. |
Source |
Synonyms | Isorhamnetin-3-O-beta-D-Glucoside |
Molecular Weight | 478.4 |
Formula | C22H22O12 |
CAS No. | 5041-82-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (522.58 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Isorhamnetin-3-O-glucoside 5041-82-7 Others Inhibitor inhibit Isorhamnetin3Oglucoside Isorhamnetin-3-O-beta-D-Glucoside Isorhamnetin 3 O glucoside Isorhamnetin-3-O-b-D-Glucoside Isorhamnetin-3-O-β-D-Glucoside inhibitor