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Benfotiamine

Name: Benfotiamine
Brand: TargetMol
SKU: T1129
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1129Cas No. 22457-89-2

Alias S-Benzoylthiamine O-monophosphate, Benzoylthiamine monophosphate

Benfotiamine (S-Benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1) employed as an antioxidant dietary supplement.

Benfotiamine

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Purity: 99.91%

Catalog No. T1129Alias S-Benzoylthiamine O-monophosphate, Benzoylthiamine monophosphateCas No. 22457-89-2

Benfotiamine (S-Benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1) employed as an antioxidant dietary supplement.

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$33	In Stock	In Stock
200 mg	$48	In Stock	In Stock
500 mg	$78	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$87	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Color:White

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COA LCMS HNMR

Product Introduction

Benfotiamine AI Summary

Benfotiamine exhibits bioactivity in assays aimed at identifying compounds that block the entry of the Ebola virus, showing potential inhibitory effects with AC50 values ranging from 63.1 nM to 0.3162 µM, indicating varying levels of potency. Additionally, it displays antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) in an imaging assay in HRCE cells, with a hit score of 0.08383, suggesting low activity in this context. Furthermore, Benfotiamine demonstrates high binding affinity and agonist/antagonist activity across a range of receptor proteins in various in vitro assays, though no significant inhibition or activity was observed at concentrations below AC50 > 30000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Benfotiamine (S-Benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1) employed as an antioxidant dietary supplement.
Synonyms	S-Benzoylthiamine O-monophosphate, Benzoylthiamine monophosphate

Chemical Properties

Molecular Weight	466.45
Formula	C₁₉H₂₃N₄O₆PS
Cas No.	22457-89-2
Smiles	C(N(C(=C(SC(=O)C1=CC=CC=C1)CCOP(=O)(O)O)C)C=O)C=2C(N)=NC(C)=NC2
Relative Density.	1.444 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (107.19 mM), Sonication is recommended.

H2O: 0.67 mg/mL (1.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (5.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1439 mL	10.7193 mL	21.4385 mL	107.1926 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.4288 mL	2.1439 mL	4.2877 mL	21.4385 mL
10 mM	0.2144 mL	1.0719 mL	2.1439 mL	10.7193 mL
20 mM	0.1072 mL	0.5360 mL	1.0719 mL	5.3596 mL
50 mM	0.0429 mL	0.2144 mL	0.4288 mL	2.1439 mL
100 mM	0.0214 mL	0.1072 mL	0.2144 mL	1.0719 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc