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Diacerein

Catalog No. T1273 CAS 13739-02-1

Synonyms: Diacerhein, Fisiodar, Diacetylrhein

Diacerein is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including sevre diarrhea [L780]. Diacerein is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Diacerein, CAS 13739-02-1

Pack Size	Availability	Price/USD	Quantity
50 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98.14%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Kinase Assay

In Vitro Growth Inhibition Assay: Stock solution of Cytarabine is prepared in absolute ethanol, and serial dilutions of Cytarabine are prepared. CCRF-CEM cells are suspended in RPMI medium supplemented with 10% FBS, 0.1% gentamicin, and 1% sodium pyruvate. The cells are suspended in their respective media to give 10 mL volumes of cell suspension at a final density of 3-6 × 104 cells/mL. Appropriate volumes of Cytarabine solution are transferred to the cell suspensions, and incubation is continued for 72 hours. The cells are spun down and resuspended in fresh Cytarabine -free medium, and final cell counts are determined. The data are analyzed by sigmoidal curve fitting of the cell count versus Cytarabine concentration, and the results are expressed as the IC50 (Cytarabine concentration that inhibits cell growth to 50% of the control value).

Synonyms	Diacerhein, Fisiodar, Diacetylrhein
Molecular Weight	368.297
Formula	C19H12O8
CAS No.	13739-02-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 45 mg/mL (122.2 mM)

Ethanol: <1 mg/mL

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yaron M, et al. Osteoarthritis Cartilage, 1999, 7(3), 272-280. 2. Felisaz N, et al. Osteoarthritis Cartilage, 1999, 7(3), 255-264. 3. Boileau C, et al. Arthritis Res Ther, 2008, 10(3), R71. 4. Tamura T, et al. Eur J Pharmacol, 2002, 448(1), 81-87. 5. Hwa SY, et al. J Rheumatol, 2001, 28(4), 825-834.

Related compound libraries

This product is contained In the following compound libraries：

Drug-induced Liver Injury (DILI) Compound Library Inhibitor Library Anti-Diabetic Compound Library Anti-Cardiovascular Disease Compound Library Cytokine Inhibitor Library Chinese Pharmacopoeia Natural Product Library Drug Repurposing Compound Library Anti-Metabolism Disease Compound Library Selected Plant-Sourced Compound Library Anti-Tumor Natural Product Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Diacerein 13739-02-1 Immunology/Inflammation Interleukin IL Receptor Interleukin Related Diacerhein Fisiodar Diacetylrhein Inhibitor inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.