c-src — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP2137L	Pp60 c-src (521-533) (phosphorylated) acetate		Others
	pp60 c-src (521-533) (phosphorylated) acetate is a regulator of focal adhesion formation and cell spreading. pp60 c-src (521-533) (phosphorylated) acetate also regulates cell motility and is a key component in the signal...		Others
TP2137	Pp60 c-src (521-533) (phosphorylated)
	Peptide corresponding to the pp60c-src carboxy terminal regulatory domain; phosphorylated at Tyr527. Binds to pp60c-src and pp60v-src at the SH2 domain, suppressing their tyrosine kinase activity and transforming potenti...
T13194	CSF1R-IN-2		c-Fms , c-Met/HGFR , Src
	CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).		c-Fms , c-Met/HGFR , Src
T8719	SC99		Apoptosis , JAK , STAT
	SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activiti...		Apoptosis , JAK , STAT
T4185	Lavendustin C	HDBA,NSC 666251	CaMK , EGFR , Tyrosinase , Src
	lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.		CaMK , EGFR , Tyrosinase , Src
T11826	LCH-7749944	GNF-PF-2356	Apoptosis , PAK
	LCH-7749944 (GNF-PF-2356) effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor w...		Apoptosis , PAK
T2609	Masitinib	AB1010	Apoptosis , FAK , c-Fms , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Hck
	Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has been distributed under the commercial name Masivet...
T8544	Masitinib mesylate	AB-1010 mesylate	Apoptosis , FAK , FGFR , PDGFR , Src , c-Kit
	Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα/β;LynB,respectively).		Apoptosis , FAK , FGFR , PDGFR , Src , c-Kit
T6028	PF 477736	PF 00477736,PF-477736,PF-736,PF-00477736,PF477736	c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase
	PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
T11745	KB SRC 4		Src
	KB SRC 4 is a selective and potent c-Src inhibitor with antitumour activity that inhibits the growth of cancer cells.		Src
T13000	Src Inhibitor 3		Others , Src
	Src Inhibitor 3 is an effective inhibitor of c-terminal Src kinase (IC50 <3 nM in CSK HTRF, <4 nM in Caliper assay). Src Inhibitor 3 increases T cell proliferation induced by T cell receptor signaling.		Others , Src
T4597	UM-164	UM164,DAS-DFGO-II	p38 MAPK , Src , Autophagy
	UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.		p38 MAPK , Src , Autophagy
T3935	1-Naphthyl PP1	1-NA-PP 1	Src
	1-Naphthyl PP1 (1-NA-PP 1) is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively)		Src
T6348	NVP-BHG712		Raf , Bcr-Abl , Src , Ephrin Receptor
	NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respecti...		Raf , Bcr-Abl , Src , Ephrin Receptor
T7371	1-Naphthyl PP1 hydrochloride	1-NA-PP 1 hydrochloride	Src
	1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases v-Src		Src
T6078	Saracatinib	AZD0530	EGFR , Src , BTK , Autophagy
	Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.		EGFR , Src , BTK , Autophagy
T22552L	AD57		Bcr-Abl , Src
	AD57 is a potent inhibitor of both c-Src and Abl with IC50 of 0.025 μM and 0.041 μM, respectively.		Bcr-Abl , Src
T8995	NCGC00262650		Others , Src
	NCGC00262650 is an inhibitor of AMA1-RON2 interaction and c-Src tyrosine kinase activity.		Others , Src
T6525	GW 5074	GW5074,Raf1 Kinase Inhibitor I	Apoptosis , Raf
	GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor. It has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms.		Apoptosis , Raf
TN1892	Lusianthridin		Others , c-Myc
	Lusianthridin is a natural product from Dendrobium venustum. Lusianthridin exhibits anti-migratory property at nontoxic concentrations. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signali...		Others , c-Myc