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NVP-BHG712

Catalog No. T6348 CAS 940310-85-0

NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.

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NVP-BHG712, CAS 940310-85-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.
Targets&IC50	C-Raf:0.395 μM, c-Abl:1.667 μM, EphB4:25 nM, c-Src:1.266 μM

Molecular Weight	503.49
Formula	C26H20F3N7O
CAS No.	940310-85-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 24.7 mg/mL(40 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Martiny-Baron G, et al. Angiogenesis. 2010, 13(3), 259-267.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NVP-BHG712 940310-85-0 Angiogenesis Cytoskeletal Signaling MAPK Tyrosine Kinase/Adaptors Src Raf Ephrin Receptor Bcr-Abl BHG 712 inhibit Inhibitor NVP BHG712 NVPBHG712 BHG-712 BHG712 NVP-BHG-712 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.