anti-metabolic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0686	Orlistat	Ro-18-0647,Tetrahydrolipstatin	Apoptosis , Others , Fatty Acid Synthase
	Orlistat (Tetrahydrolipstatin) is an Intestinal Lipase Inhibitor. The mechanism of action of orlistat is as a Lipase Inhibitor.		Apoptosis , Others , Fatty Acid Synthase
TN2121	3,5,7,3′,4′-Pentamethoxyflavone	Quercetin 3,5,7,3,4-pentamethyl ether	Others
	3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) is a natural product. It can induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation.		Others
T3324	Lycorine	Galanthidine,Narcissine,Amarylline,Belamarine,Licorine	Apoptosis , Virus Protease , Antibacterial , AChR , Fatty Acid Synthase
	Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.
T27019	PSB-CB5	CID-85469571,GPR18-IN-32	GPR
	PSB-CB5 (GPR18-IN-32)2 is a GRP18 antagonist with anti-inflammatory activity and can be used to study obesity and metabolic disorders.		GPR
T26701	AZ12216052	AZ 12216052,AZ-12216052	GPR
	AZ12216052 is a GRP8 antagonist with anxiolytic and anti-inflammatory activity and can be used to study obesity and metabolic disorders.		GPR
T3S0289	Araloside X		Calcium Channel
	Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane perox...		Calcium Channel
T6S1683	Demethoxycurcumin	Curcumin II,Desmethoxycurcumin,Monodemethoxycurcumin	Apoptosis , Antioxidant , Antibacterial , Autophagy
	1. Demethoxycurcumin (Desmethoxycurcumin) has antioxidant activity. 2. Demethoxycurcumin has anti-inflammatory activity. 3. Demethoxycurcumin has anti-proliferative activity. 4. Demethoxycurcumin has anti-acanthamoebic e...		Apoptosis , Antioxidant , Antibacterial , Autophagy
T13159	Tiludronate disodium	Tiludronic Acid disodium,Tiludronic acid disodium	ATPase
	Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disor...		ATPase
T1163	Betamethasone valerate	Betnovate,Betaderm,Betamethasone 17-valerate,Luxiq	Glucocorticoid Receptor
	Betamethasone valerate (Luxiq) is a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions.		Glucocorticoid Receptor
T3669	Curcumenol	(+)-Curcumenol	P450
	Curcumenol ((+)-Curcumenol), one of the major components of Zedoary turmeric oil, is an antibiotic drug which has anti-Y, anti-inflammation activity. Curcumenol may be safely used without inducing metabolic drug-drug int...		P450
T3S0381	Chrysophanol 8-O-glucoside		Serine Protease
	Chrysophanol 8-O-glucoside and chrysophanol have mild cytotoxicity and anti-diabetic properties and can play metabolic roles in the insulin-stimulated glucose transport pathway		Serine Protease
T0977	Medrysone	Gimeracil,6α-Methyl-11β-hydroxyprogesterone	Glucocorticoid Receptor , Others
	Medrysone (6α-Methyl-11β-hydroxyprogesterone) is a topical, synthetic glucocorticoid with metabolic, anti-inflammatory and anti-allergic properties. Medrysone exerts its effect by interacting with specific intracellular ...		Glucocorticoid Receptor , Others
T1559	Betamethasone dipropionate	Diprolene AF,SCH 11460,Betamethasone 17,21-dipropionate,Diprolene,Diprosone	Glucocorticoid Receptor
	Betamethasone Dipropionate is the 17, 21-dipropionate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions. Betamethasone dipropionate (SCH 11460) binds to sp...		Glucocorticoid Receptor
T60400	LDCA		Apoptosis , Dehydrogenase
	LDCA is a double-hit metabolic regulator that exhibits potent anti-proliferative activity. lDCA competitively inhibits LDH-A enzyme activity, alters mitochondrial hyperpolarization and simultaneously subverts apoptosis. ...		Apoptosis , Dehydrogenase
T2S2173	(E)-Naringenin chalcone	Isosalipurpol,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone	Others
	Naringenin chalcone (Isosalipurpol) has antiallergic activity Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells. Naringenin chalcone is a potent tomato flavonoid tha...		Others
T5S1172	Tiliroside	Tribuloside	Antioxidant
	1. Tiliroside (Tribuloside) shows anticarcinogenic activity. 2. Tiliroside shows hepatoprotective activity. 3. Tiliroside shows antioxidant and anti-inflammatory activity, can inhibit neuroinflammation in neurodegenerati...		Antioxidant
T3403	Glabridin	Q-100692,KB-289522,LS-176045	Reactive Oxygen Species , Tyrosinase , GABA Receptor , Antibacterial , PPAR
	Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on...
T1185	Rofecoxib	MK 966,MK-0966	COX
	Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of pheny...		COX
T60877	Mtb ATP synthase-IN-1
	Mtb ATP synthase-IN-1 (compound 6ab) can be used in anti-mycobacterium research. Mtb ATP synthase-IN-1 shoys low cytotoxicity (Vero IC 50 > 64 μg/mL) and acceptable oral bioavailability that has good metabolic stability....
T5S1097	Neferine	(R)-1,2-Dimethoxyaporphine,(-)-Neferine	Apoptosis , NF-κB , Autophagy
	1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to a...		Apoptosis , NF-κB , Autophagy