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Endocrinology/Hormones Glucocorticoid Receptor Betamethasone dipropionate

Betamethasone dipropionate

Catalog No. T1559   CAS 5593-20-4
Synonyms: Betamethasone 17,21-dipropionate, SCH 11460, Diprosone, Diprolene, Diprolene AF

Betamethasone Dipropionate is the 17, 21-dipropionate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions. Betamethasone dipropionate binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.

Betamethasone dipropionate, CAS 5593-20-4
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Betamethasone Dipropionate is the 17, 21-dipropionate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions. Betamethasone dipropionate binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.
Targets&IC50 Glucocorticoid Receptor,  
Synonyms Betamethasone 17,21-dipropionate , SCH 11460 , Diprosone , Diprolene , Diprolene AF
Purity 97.82%
Molecular Weight 504.59
Formula C28H37FO7
CAS No. 5593-20-4

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

Ethanol: 66 mg/mL (130.79 mM)

DMSO: 101 mg/mL (200.16 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Park JM, et al. J Am Acad Dermatol. 2013 Sep;69(3):492-3.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-infection Compound Library Endocrinology-Hormones Library FDA-approved Drug Library GPCR Compound Library Fluorochemical Library Anti-Metabolism Disease Compound Library

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Dexamethasone BecloMethasone Finerenone Glucagon hydrochloride (16941-32-5 free base) GW-870086 AZD7594 Esaxerenone Relacorilant

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