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Glabridin

Catalog No. T3403   CAS 59870-68-7
Synonyms: Q-100692, KB-289522, LS-176045

Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.

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Glabridin Chemical Structure
Glabridin, CAS 59870-68-7
Pack Size Availability Price/USD Quantity
20 mg In stock $ 80.00
100 mg In stock $ 191.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Purity: 99.78%
Purity: 98.01%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders( such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.
Targets&IC50 α1β1γ2 (GABAA receptor):17.23 μM(EC50), α1β2 (GABAA receptor):9.63 μM(EC50), α1β3γ2 (GABAA receptor):6.83 μM(EC50), α1β2γ2 (GABAA receptor):6.3 μM(EC50)
Source
Synonyms Q-100692, KB-289522, LS-176045
Molecular Weight 324.37
Formula C20H20O4
CAS No. 59870-68-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 58 mg/mL(178.8 mM)

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

TargetMolReferences and Literature

1. Yokota Tm , et al. Pigment Cell Res. 1998 Dec;11(6):355-61. 2. Yehuda I, et al. Mol Nutr Food Res. 2015 Jun;59(6):1041-52. 3. Hsieh MJ, et al. Br J Pharmacol. 2014 Jun;171(12):3037-50. 6. El-Ashmawy NE, et al. Downregulation of iNOS and elevation of cAMP mediate the anti-inflammatory effect of glabridin in rats with ulcerative colitis. Inflammopharmacology. 2018 Apr;26(2):551-559.

TargetMolCitations

1. Yan Y, Xia X, Fatima A, et al.Antibacterial Activity and Mechanisms of Plant Flavonoids against Gram-Negative Bacteria Based on the Antibacterial Statistical Model.Pharmaceuticals.2024, 17(3): 292.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Anti-Cancer Active Compound Library Anti-Infection Compound Library Polyphenolic Natural Product Library Pyroptosis Compound Library Antioxidant Compound Library Natural Product Library for HTS Chinese Pharmacopoeia Natural Product Library Anti-Alzheimer's Disease Compound Library Selected Plant-Sourced Compound Library

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Keywords

Glabridin 59870-68-7 DNA Damage/DNA Repair Immunology/Inflammation Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb Proteases/Proteasome PPAR GABA Receptor Antibacterial Tyrosinase Reactive Oxygen Species LS 176045 KB289522 Peroxisome proliferator-activated receptors Q 100692 Bacterial inhibit KB 289522 Q100692 Q-100692 KB-289522 LS-176045 LS176045 Inhibitor inhibitor

 

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