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AZ12216052

Catalog No. T26701 CAS 1290628-31-7

Synonyms: AZ 12216052, AZ-12216052

AZ12216052 is a GRP8 antagonist with anxiolytic and anti-inflammatory activity and can be used to study obesity and metabolic disorders.

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AZ12216052, CAS 1290628-31-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 100.00
2 mg	In stock	$ 147.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 396.00
25 mg	In stock	$ 648.00
50 mg	In stock	$ 912.00
100 mg	In stock	$ 1,220.00
500 mg	In stock	$ 2,460.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	AZ12216052 is a GRP8 antagonist with anxiolytic and anti-inflammatory activity and can be used to study obesity and metabolic disorders.
In vitro	In UN- and RA-SH-SY5Y cells, AZ 12216052 (0.01-1 μM; 48 hours) increased cell viability at 0.1 μM and protected undifferentiated neuroblastoma cells against the damaging effects of Iri or Cis[2].
In vivo	AZ 12216052 (10 mg/kg; intraperitoneal injection; single dose, 2 hours prior to testing) reduced the increased anxiety levels in ApoE−/− and C57BL/6J mice in the zero maze without affecting the speed of the mice. Additionally, it decreased the acoustic startle response[3].

Synonyms	AZ 12216052, AZ-12216052
Molecular Weight	392.35
Formula	C19H22BrNOS
CAS No.	1290628-31-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (203.90 mM), Sonication is recommended.

References and Literature

1. Reed BT, et al. Differential modulation of retinal ganglion cell light responses by orthosteric and allosteric metabotropic glutamate receptor 8 compounds. Neuropharmacology. 2013 Apr;67:88-94. 2. Jantas D, et al. Allosteric and Orthosteric Activators of mGluR8 Differentially Affect the Chemotherapeutic-Induced Human Neuroblastoma SH-SY5Y Cell Damage: The Impact of Cell Differentiation State. Basic Clin Pharmacol Toxicol. 2018 Oct;123(4):443-451. 3. Duvoisin RM, et al. Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav Brain Res. 2010 Oct 15;212(2):168-73. 4. Duvoisin RM, et al. Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges. Behav Brain Res. 2011 Aug 1;221(1):50-4.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AZ12216052 1290628-31-7 Endocrinology/Hormones GPCR/G Protein GPR AZ 12216052 AZ-12216052 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.