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Tiludronate disodium

Catalog No. T13159 CAS 149845-07-8

Synonyms: Tiludronic Acid disodium, Tiludronic acid disodium

Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders.

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Tiludronate disodium, CAS 149845-07-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 196.00
25 mg	In stock	$ 347.00
50 mg	In stock	$ 516.00
100 mg	In stock	$ 736.00
500 mg	In stock	$ 1,480.00

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Purity: 100%

Biological Description

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Description	Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders.
In vitro	Tiludronate displays potent inhibitory against proton transport in yeast microsomal preparations with an IC50 of 3.5 μM and inhibits the activity of purified yeast V-ATPase. Tiludronate inhibits proton transport with IC50s of 1.1 mM and 466 nM in kidney-derived vesicles and vesicles derived from osteoclasts[3].
In vivo	Tiludronate dose-dependently inhibits the resorption of bones. Tiludronate reduces the secrete proton of mature osteoclasts into the resorption space and favors the detachment of mature osteoclasts from the bone matrix. Oral administration of Tiludronate (5-200 mg/kg) prevents the decrease in the skeletal mass in the castrated male rat model[3].

Synonyms	Tiludronic Acid disodium, Tiludronic acid disodium
Molecular Weight	362.57
Formula	C7H7ClNa2O6P2S
CAS No.	149845-07-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 56.2 mg/mL (155.1 mM), Sonification is recommended.

References and Literature

1. Reginster JY, et al. Prevention of postmenopausal bone loss by tiludronate. Lancet. 1989 Dec 23-30;2(8678-8679):1469-71. 2. Nunes NLT, et al. Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats. J Periodontol. 2018 Jan;89(1):105-116. 3. Bonjour JP, et al. Tiludronate: bone pharmacology and safety. Bone. 1995;17(5 Suppl):473S-477S. 4. David P, et al. The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. J Bone Miner Res. 1996;11(10):1498-1507.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Approved Drug Library Bioactive Compounds Library Max Mitochondria-Targeted Compound Library FDA-Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library

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Keywords

Tiludronate disodium 149845-07-8 Membrane transporter/Ion channel ATPase Tiludronic Acid disodium Tiludronate Tiludronic acid Tiludronic acid disodium inhibitor inhibit

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