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Tiludronate disodium

Catalog No. T13159 CAS 149845-07-8

Synonyms: Tiludronic acid disodium

Tiludronate disodium is an osteoclast vacuolar H(+)-<a href="/target/ATPase" style="display: inline; color: #c13a36">ATPase</a> inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders.

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Tiludronate disodium, CAS 149845-07-8

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5 mg	In stock	$ 138.00
10 mg	In stock	$ 228.00
25 mg	In stock	$ 349.00

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Purity: 100%

Biological Description

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Description	Tiludronate disodium is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders.
In vitro	Tiludronate displays potent inhibitory against proton transport in yeast microsomal preparations with an IC50 of 3.5 μM and inhibits the activity of purified yeast V-ATPase. Tiludronate inhibits proton transport with IC50s of 1.1 mM and 466 nM in kidney-derived vesicles and vesicles derived from osteoclasts[3].
In vivo	Tiludronate dose-dependently inhibits the resorption of bones. Tiludronate reduces the secrete proton of mature osteoclasts into the resorption space and favors the detachment of mature osteoclasts from the bone matrix. Oral administration of Tiludronate (5-200 mg/kg) prevents the decrease in the skeletal mass in the castrated male rat model[3].

Synonyms	Tiludronic acid disodium
Molecular Weight	362.56
Formula	C7H7ClNa2O6P2S
CAS No.	149845-07-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 56.2 mg/mL (155.1 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Reginster JY, et al. Prevention of postmenopausal bone loss by tiludronate. Lancet. 1989 Dec 23-30;2(8678-8679):1469-71. 2. Nunes NLT, et al. Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats. J Periodontol. 2018 Jan;89(1):105-116. 3. Bonjour JP, et al. Tiludronate: bone pharmacology and safety. Bone. 1995;17(5 Suppl):473S-477S. 4. David P, et al. The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. J Bone Miner Res. 1996;11(10):1498-1507.

Related compound libraries

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Keywords

Tiludronate disodium 149845-07-8 Membrane transporter/Ion channel ATPase Tiludronic acid disodium Inhibitor inhibitor inhibit

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