Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Tiludronate disodium is an osteoclast vacuolar H(+)-<a href="/target/ATPase" style="display: inline; color: #c13a36">ATPase</a> inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 50.00 | |
5 mg | In stock | $ 138.00 | |
10 mg | In stock | $ 228.00 | |
25 mg | In stock | $ 349.00 |
Description | Tiludronate disodium is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders. |
In vitro | Tiludronate displays potent inhibitory against proton transport in yeast microsomal preparations with an IC50 of 3.5 μM and inhibits the activity of purified yeast V-ATPase. Tiludronate inhibits proton transport with IC50s of 1.1 mM and 466 nM in kidney-derived vesicles and vesicles derived from osteoclasts[3]. |
In vivo | Tiludronate dose-dependently inhibits the resorption of bones. Tiludronate reduces the secrete proton of mature osteoclasts into the resorption space and favors the detachment of mature osteoclasts from the bone matrix. Oral administration of Tiludronate (5-200 mg/kg) prevents the decrease in the skeletal mass in the castrated male rat model[3]. |
Synonyms | Tiludronic acid disodium |
Molecular Weight | 362.56 |
Formula | C7H7ClNa2O6P2S |
CAS No. | 149845-07-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: 56.2 mg/mL (155.1 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Tiludronate disodium 149845-07-8 Membrane transporter/Ion channel ATPase Tiludronic acid disodium Inhibitor inhibitor inhibit