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Tiludronate disodium

Tiludronate disodium
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Purity:100%
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Tiludronate disodium

Catalog No. T13159Cas No. 149845-07-8
Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders.
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Pack SizePriceAvailabilityQuantity
5 mg$73In Stock
10 mg$117In Stock
25 mg$198In Stock
50 mg$297In Stock
100 mg$441In Stock
500 mg$888In Stock
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Product Introduction

Bioactivity
Description
Tiludronate disodium (Tiludronic acid disodium) is an osteoclast vacuolar H(+)-ATPase inhibitor with antiresorptive and anti-inflammatory properties. Tiludronate disodium can be used in studies about metabolic bone disorders.
In vitro
Tiludronate displays potent inhibitory against proton transport in yeast microsomal preparations with an IC50 of 3.5 μM and inhibits the activity of purified yeast V-ATPase. Tiludronate inhibits proton transport with IC50s of 1.1 mM and 466 nM in kidney-derived vesicles and vesicles derived from osteoclasts[3].
In vivo
Tiludronate dose-dependently inhibits the resorption of bones. Tiludronate reduces the secrete proton of mature osteoclasts into the resorption space and favors the detachment of mature osteoclasts from the bone matrix. Oral administration of Tiludronate (5-200 mg/kg) prevents the decrease in the skeletal mass in the castrated male rat model[3].
AliasTiludronic Acid disodium, Tiludronic acid disodium
Chemical Properties
Molecular Weight362.57
FormulaC7H7ClNa2O6P2S
Cas No.149845-07-8
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 56.2 mg/mL (155.1 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM2.7581 mL13.7904 mL27.5809 mL137.9044 mL
5 mM0.5516 mL2.7581 mL5.5162 mL27.5809 mL
10 mM0.2758 mL1.3790 mL2.7581 mL13.7904 mL
20 mM0.1379 mL0.6895 mL1.3790 mL6.8952 mL
50 mM0.0552 mL0.2758 mL0.5516 mL2.7581 mL
100 mM0.0276 mL0.1379 mL0.2758 mL1.3790 mL

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