u87 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5784	Topotecan	NSC 609669,SKF 104864A	Topoisomerase , Autophagy
	Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.		Topoisomerase , Autophagy
T2430	HPOB		Apoptosis , HDAC
	HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.		Apoptosis , HDAC
T5622	BAY-218	AHR antagonist 1	AhR , Aryl Hydrocarbon Receptor
	BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line.		AhR , Aryl Hydrocarbon Receptor
T6920	ON123300		FGFR , c-RET , JAK , CDK , PDGFR , Src , AMPK
	ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).		FGFR , c-RET , JAK , CDK , PDGFR , Src , AMPK
T5429	Theaflavin 3,3'-digallate	8-Gingerol,TFDG	Virus Protease , Antioxidant , HIV Protease , HSV
	Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregul...		Virus Protease , Antioxidant , HIV Protease , HSV
T5858	Sertindole	Lu 23-174	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
	Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T26930	BW-1370U87	1370U 87,1370U-87,1370U87,BW 1370U87
	BW-1370U87 is a monoamine oxidase A (MAO-A) inhibitor. BW-1370U87 elevates neurotransmitter amines in the brain over the same dose range at which it exhibits positive activities in animal models of depressive illness. BW...
T4928	L-Kynurenine	(S)-Kynurenine	AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite
	L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has ...		AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite
T8190	5-Hydroxyflavone		Others
	5-Hydroxyflavone is a natural product		Others
T1166	Ellipticine	NSC 71795,Elliptisine	Topoisomerase
	Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, and 1.48±0.62 μM for Leukemia HL-6...		Topoisomerase
T8966	ML-298	ML298,CID53393915	Phospholipase
	ML-298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM).		Phospholipase
T3213	Hematoporphyrin dihydrochloride	Hematoporphyrin IX dihydrochloride	Apoptosis , Others , Endogenous Metabolite
	Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) is a substrate for affinity chromatography of heme-binding proteins.		Apoptosis , Others , Endogenous Metabolite
T81184	Sec61-IN-4
	Sec61-IN-4 (Compound 16b) is a potent Sec61 inhibitor with an IC50 value of 0.04 nM in U87-MG cells [1].
T63624	Exatecan-amide-cyclopropanol
	Exatecan-amide-cyclopropanol is an anticancer agent that inhibits the proliferation of SK-BR-3 cells (IC50: 0.12 nM) and U87 cells (IC50: 0.23 nM).
T78804	PI3Kα-IN-12		PI3K
	PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values of 0.83 and 1.25 μM, respectively. Intraperitoneal administr...		PI3K
T38004	ML-309 (hydrochloride)
	ML-309 is an inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). It reversibly and selective inhibits IDH1R132H over wild-type IDH1 (IC50s = 96 and 36,500 nM, respectively). ML-309 reduces 2-hydroxyglutarate productio...
T81469	PI3Kα-IN-14		PI3K
	PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting in cell cycle arrest at the G1 phase and apoptosis in U87-MG cel...		PI3K
T78862	EGFR-IN-86		EGFR
	EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cell cycle arrest in U87 cells [1].		EGFR
T62060	NF-κB-IN-5
	NF-κB-IN-5 (compound 4d) is an orally active NF-κB inhibitor. NF-κB-IN-5 interacts directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines, with IC 50 values of 5.35, 2.81, 2.83, 2.02 and...
T70890	ML309
	ML309 is a potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells. ML309 is capable of potent and selective inhibition of mutant IDH1 and effectively lowers c...