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Ellipticine

Catalog No. T1166 CAS 519-23-3

Synonyms: NSC 71795, Elliptisine

Ellipticine (Elliptisine) is a potent antineoplastic agent exhibiting multiple mechanisms of action, IC50 of 0.67±0.06, 1.25±0.13, 1.25±0.13, 0.67±0.06, 0.27±0.02, 0.49±0.04, 0.44±0.03, and 1.48±0.62 μM for Leukemia HL-60, Breast adenocarcinoma MCF-7, Breast adenocarcinoma MCF-7, Leukemia HL-60, Neuroblastoma IMR-32, Neuroblastoma UKF-NB-4, Neuroblastoma UKF-NB-3, and Glioblastoma U87 mg cell, respectively.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ellipticine, CAS 519-23-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 119.00
50 mg	In stock	$ 176.00
100 mg	In stock	$ 262.00
500 mg	In stock	$ 642.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.88%

Purity: 98.17%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

IMR-32 cells:0.27±0.02μM, MCF-7 cells:1.25±0.13μM, UKF-NB-3 cells:0.44±0.03μM , HL-60 cells (leukemia):0.67±0.06μM, UKF-NB-4 cells:0.49±0.04μM, U-87 MG cells (Glioblastoma):1.48±0.62 μM

Synonyms	NSC 71795, Elliptisine
Molecular Weight	246.31
Formula	C17H14N2
CAS No.	519-23-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (20.3 mM)

References and Literature

1. Savorani C, et al. Leuk Lymphoma. 2015 Mar;56(3):739-47.

Citations

1. Oh J, Lee H H, Jeong Y, et al. Paradoxical Pro-angiogenic Effect of Low-Dose Ellipticine Identified by In Silico Drug Repurposing. International Journal of Molecular Sciences. 2021, 22(16): 9067.

Related compound libraries

This product is contained In the following compound libraries：

Antiparasitic Natural Product Library Anti-Cancer Active Compound Library Chinese Pharmacopoeia Natural Product Library Anti-Cancer Compound Library Bioactive Compound Library RO5 Drug-like Natural Product Library Bioactive Compounds Library Max Anti-Tumor Natural Product Library Natural Product Library for HTS DNA Damage & Repair Compound Library

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Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ellipticine 519-23-3 DNA Damage/DNA Repair Topoisomerase NSC71795 Inhibitor NSC 71795 NSC-71795 Elliptisine inhibit inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.