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5-Hydroxyflavone
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Catalog No. T8190Cas No. 491-78-1
5-Hydroxyflavone is a natural product
5-Hydroxyflavone
Copy Product Info🥰Excellent
Purity: 99.96%
Catalog No. T8190Cas No. 491-78-1
5-Hydroxyflavone is a natural product
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.96%
Color:White to Yellow
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Product Introduction
5-Hydroxyflavone AI Summary
5-Hydroxyflavone exhibits a diverse range of bioactivities across various biological systems. It acts as an inhibitor of COX-2 catalyzed PGE-2 production, showing a 45.0% inhibition at 10 µM concentration in LPS-induced RAW 264.7 cells. The compound demonstrates binding affinity to multiple receptors, including the benzodiazepine receptor (Ki of 1900 nM) and various adenosine receptors with moderate affinity (Ki values: 2170 nM for A1, 6200 nM for A2A, and displaces 47.0% of [125I]AB-MECA binding from A3 receptor).
In mitochondrial enzyme assays, 5-Hydroxyflavone shows significant inhibitory activity, notably on beef heart mitochondrial succinoxidase (95.7%) and rat liver mitochondrial ATPase (98.9%). Additionally, it displays hypochlorous acid scavenging activity with 17.0% inhibition of DHR oxidation at 50 µM.
In terms of cytotoxicity, it exhibits an ED50 value of 20.0 µg/ml against human KB cells and enhances DNA cleavage mediated by human DNA topoisomerase 2 in E. coli pUC8 DNA. As an antagonist, it inhibits the androgen receptor with an IC50 of 300 nM and shows agonist activity in glucocorticoid receptor assays.
The compound displays gastroprotective effects, providing 58.0% protection from gastric damage in rats at 20 mg/kg intraperitoneally. It also has antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 (IC50 of 65900 nM) and antitrypanosomal activity against Trypanosoma brucei brucei (IC50 < 30000 nM).
Furthermore, 5-Hydroxyflavone exhibits antiviral activity against SARS-CoV-2, with an IC50 value greater than 20000 nM and shows potential in modulating lipid storage and activating various enzymes like Cytochrome P450 3A4.
Overall, 5-Hydroxyflavone presents a broad pharmacological profile, making it a candidate for further investigation in various therapeutic areas including inflammation, gastroprotection, infectious diseases, and enzyme modulation..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 5-Hydroxyflavone is a natural product |
| Molecular Weight | 238.24 |
| Formula | C15H10O3 |
| Cas No. | 491-78-1 |
| Smiles | Oc1cccc2oc(cc(=O)c12)-c1ccccc1 |
| Relative Density. | 1.34g/cm3 |
| Storage | keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 2.2 mg/mL (9.23 mM), Sonication is recommended.  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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