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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12731 | RIPK1-IN-7 | RIP kinase | |
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model. | |||
T0678 | Amitriptyline hydrochloride | Amitriptyline HCl,Tryptizol,Domical,Annoyltin | Trk receptor , Sigma receptor , 5-HT Receptor , Serotonin Transporter , Sodium Channel , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor |
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. | |||
T4349 | Sitravatinib | MG516,MGCD516 | Discoidin Domain Receptor (DDR) , VEGFR , FLT , Trk receptor , TAM Receptor , c-Kit , Ephrin Receptor |
Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl. | |||
T14363 | AZ-23 | AZ 23,AZ23 | Trk receptor |
AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively. | |||
T6097 | GNF-5837 | GNF 5837 | Trk receptor , PDGFR , c-Kit |
GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM). | |||
T5635 | CH7057288 | Trk receptor | |
CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively. | |||
T4257 | Belizatinib | TSR-011 | Trk receptor , ALK |
Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC. | |||
T3678 | Entrectinib | RXDX-101,NMS-E628 | Trk receptor , ROS , ALK , Autophagy , ROS Kinase |
Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectini... | |||
T41224 | CG 428 | Trk receptor | |
CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM. CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 joined by a linker to the cereblon E3 ligase ligand pomalidom... | |||
T2349 | BMS-754807 | Trk receptor , c-Met/HGFR , IGF-1R | |
Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity. | |||
T17170 | PF-06737007 | Trk receptor | |
PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively). | |||
T13207 | PF-06733804 | Trk receptor | |
PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect. | |||
T17169 | Trk-IN-4 | PF-6683324 isomer | Trk receptor |
Trk-IN-4 is an effective pan-Trk inhibitor in cell-based assays (IC50s: 1.9 nM, 2.6 nM, and 1.1 nM for TrkA, TrkB, and TrkC, respectively). | |||
T14921 | CE-245677 | Tie-2 , Trk receptor | |
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM. | |||
T73306 | TrkA-IN-3 | ||
TrkA-IN-3 is a potent, subselective, and allosteric inhibitor of TrkA, demonstrating significant potency with an IC50 of 22.4 nM. It exhibits over 8000-fold selectivity towards TrkA in comparison to TrkB and TrkC, making... | |||
T61551 | Trk-IN-20 | ||
Trk-IN-20 is a 3-vinylindazole derivative compound that effectively inhibits the functions of Trk kinases. It accomplishes this by suppressing the phosphorylation of TrkA, TrkB, and TrkC, with IC50 values of 1.6 nM, 2.9 ... | |||
T73033 | TRK II-IN-1 | Trk receptor | |
TRK II-IN-1 is a potent type II inhibitor of tropomyosin receptor kinases (TRK), demonstrating inhibitory half-maximal inhibitory concentrations (IC50s) of 3.3, 6.4, 4.3, and 9.4 nM against TRKA, TRKB, TRKC, and the muta... | |||
T12925 | Sitravatinib malate | MGCD516 malate,MG-516 malate | TAM Receptor |
Sitravatinib malate is an orally bioavailable receptor inhibitor of tyrosine kinase (RTK) (IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT... | |||
T61443 | Trk-IN-7 | ||
Trk-IN-7 (compound I-6) is a highly potent inhibitor of TRK, exhibiting IC50 values ranging from 0.25-10 nM for TRKA, TRKB, and TRKC, respectively. In addition, Trk-IN-7 demonstrates notable inhibition against EML4-ALK (... | |||
T63076 | IHMT-TRK-284 | ||
IHMT-TRK-284 (Compound 34) is a potent, orally active type II TRK kinase inhibitor that acts on TRKA (IC50: 10.5 nM), TRKB (IC50: 0.7 nM), and TRKC (IC50: 2.6 nM). IHMT-TRK-284 exhibits good selectivity in the kinase gro... |