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Search Result

Search Results for " stat1 "

Targets

Apoptosis Nucleoside Antimetabolite/Analog DNA/RNA Synthesis STAT

17

Compounds

6

Natural Products

26

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T1038 Fludarabine NSC 118218,Fludarabinum,F-ara-A Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , STAT
Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor activity and can be used for the treatment of leukemia and...
T2168 2-(1,8-naphthyridin-2-yl)phenol STAT
2-NP is a STAT1 enhancer.
T35544 ML115 STAT
ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.
T2505 S3I-201 S3I 201,S3I201 STAT
S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.
T72029 CDK8-IN-13 Apoptosis , CDK
CDK8-IN-13 is a CDK8 inhibitor (IC50: 51.9 nM) with potent, selective and oral activity. CDK8-IN-13 induces apoptosis and reduces the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 exhibits anti-tumour activity...
T1563 Nifuroxazide Diarlidan,Nifuroxazid,Dicoferin Antibacterial , Antibiotic , STAT
Nifuroxazide (Diarlidan) is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STAT1/3/5 transcription.
TQ0037 Abrocitinib PF-04965842 JAK
Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).
T21501 5,15-DPP
5,15-Diphenylporphyrin (5,15-DPP) is a selective STAT3-SH2 antagonist with IC 50s of 0.28 μM and 10 μM for STAT3 and STAT1, respectively [1].
T73472 Erasin
Erasin, a formidable antagonist to Erlotinib resistance, selectively inhibits STAT3 with an IC50 of 9.7 μM, and STAT1 with an IC50 of 24 μM. It effectively induces apoptosis in cancer cells [1].
T71156 Poloxipan
Poloxipan is a potent and pan-specific PLK1 inhibitor. In vitro, Poloxipan has IC50 3.2 uM (Plk1); 1.7 uM (Plk2); and 3 uM (Plk3). Poloxipan showed minor inhibition over FHA dommain of Chk2, S2 domian of STAT1, STAT5b, L...
T26895 BRD0476 BRD-0476,ML 187,ML187,ML-187,BRD 0476
BRD0476 is a suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell ...
T61779 STAT3-IN-9
STAT3-IN-9, a potent inhibitor of STAT3 activation at Tyr705, exhibits no impact on the phosphorylation of STAT1 at Tyr 701. Additionally, this compound efficiently induces apoptosis and cell cycle arrest specifically at...
T26936 C188 Cpd188,STAT3-IN-C188,Cpd-188,C 188,C-188
C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, ...
T77038 Interferon alfa
Interferon alfa, a type I interferon, activates new genes, displaying strong antiviral and antiproliferative effects on target cells. It signals through receptor-mediated activation of Stat1 and Stat2, which heterodimeri...
T74784 LL-K8-22
LL-K8-22 is a potent, selective, and durable dual degrader of CDK8-cyclin C, demonstrating DC50 values of 2.52 and 2.64 μM, respectively. This compound effectively suppresses STAT1 Ser 727 phosphorylation and inhibits ca...
T36645 CAY10763 CAY10763
CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position...
T68182 3-Hydroxykynurenamine
3-Hydroxykynurenamine, also known as 3-Hydroxy-L-kynurenamine or 3-HKA, is a biogenic amine produced via an alternative pathway of tryptophan metabolism. In vitro, 3-HKA has an anti-inflammatory profile by inhibiting the...
Cat No. Product Name Synonyms Targets
T14854 Caerulomycin A Cerulomycin,Caerulomycin Antifungal
Caerulomycin A (Caerulomycin) (Cerulomycin; Caerulomycin) is an antifungal compound. Which induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antif...
T2814 Cryptotanshinone Cryptotanshinon,Tanshinone c STAT , Autophagy
Cryptotanshinone (Cryptotanshinon), a STAT3 inhibitor (IC50: 4.6 μM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effect on STAT3 Ser727, but no inhibition for STAT1 nor STAT5.
T5681 ETHYL CAFFEATE ETHYL 3,4-DIHYDROXYCINNAMATE NF-κB , COX , PGE Synthase , NO Synthase
Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related s...
T3824 Jaceosidin Apoptosis , BCL , COX , UGT
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...
T6677 Sophocarpine ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
TN6366 Lupinalbin A
Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokine...

Natural Products

Caerulomycin A
T14854
Synonym: Cerulomycin,Caerulomycin
Target: Antifungal
Cryptotanshinone
T2814
Synonym: Cryptotanshinon,Tanshinone c
Target: STAT, Autophagy
ETHYL CAFFEATE
T5681
Synonym: ETHYL 3,4-DIHYDROXYCINNAMATE
Target: NF-κB, COX, PGE Synthase, NO Synthase
Jaceosidin
T3824
Synonym:
Target: Apoptosis, BCL, COX, UGT
Sophocarpine
T6677
Synonym:
Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT
Lupinalbin A
TN6366
Synonym:
Target:

Recombinant Proteins

Species：
Human (9)
Mouse (5)
Cynomolgus (4)
Horse (2)
Rat (2)
Sus scrofa (Pig) (2)
Goat (1)
Rhesus (1)
Expression System：
E. coli (13)
HEK293 Cells (9)
P. pastoris (Yeast) (3)
Baculovirus Insect Cells (1)
Tag：
C-6xHis (4)
N-6xHis (4)
N-6xHis-SUMO (3)
Tag Free (3)
C-hFc (2)
6xHis (1)
C-His (1)
C-hFC (1)
His (1)
His, GST (1)
Cat No. Product Name Species Expression System
TMPJ-00961 STAT1 Protein, Human, Recombinant Human E. coli
Signal Transducer and Activator of Transcription 1-Alpha/Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer term...
TMPY-02240 STAT1 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate t...
TMPJ-00166 SCF Protein, Mouse, Recombinant Mouse E. coli
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gameto...
TMPH-01322 FANCC Protein, Human, Recombinant (His & SUMO) Human E. coli
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG...
TMPH-03110 Erythropoietin Protein, Pig, Recombinant (His) Sus scrofa (Pig) P. pastoris (Yeast)
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activa...
TMPH-00827 Erythropoietin Protein, Horse, Recombinant (hFc) Horse HEK293 Cells
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activa...
TMPH-02426 Erythropoietin Protein, Cynomolgus, Recombinant (His & Myc) Cynomolgus HEK293 Cells
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activa...
TMPH-03287 EPOR Protein, Rat, Recombinant (His & SUMO) Rat E. coli
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also ...
TMPH-00828 Erythropoietin Protein, Horse, Recombinant (His & SUMO) Horse E. coli
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activa...
TMPH-03111 Erythropoietin Protein, Pig, Recombinant (B2M & His) Sus scrofa (Pig) E. coli
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activa...
TMPH-02427 Erythropoietin Protein, Cynomolgus, Recombinant (His & SUMO) Cynomolgus E. coli
Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activa...
TMPH-02740 IL-31R alpha Protein, Mouse, Recombinant (His) Mouse E. coli
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation ch...
TMPH-02732 IFNAR2 Protein, Mouse, Recombinant (His) Mouse P. pastoris (Yeast)
Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway. Directly involved in signal transduction through its association with the TYR kinase JAK1. Involved in interferon-me...
TMPK-00026 IL-9 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pl...
TMPK-00568 IL-9 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pl...
TMPH-01559 IL-26 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expre...
TMPH-01560 IL-26 Protein, Human, Recombinant (His & Trx) Human E. coli
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expre...
TMPH-00775 IFN gamma Protein, Goat, Recombinant (His & Myc) Goat E. coli
Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentatio...
TMPU-00003 STAT2 Protein, Human, Recombinant (His) Human E. coli
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading...
TMPK-00025 IL-9 Protein, Human, Recombinant (hFc) Human HEK293 Cells
IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pl...
TMPJ-00894 SCF Protein, Rat, Recombinant (His) Rat E. coli
Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesi...
TMPJ-00331 IFNAR1 Protein, Rhesus macaque, Recombinant (His) Rhesus HEK293 Cells
Interferon‑alpha/beta receptor 1 (IFN‑ alpha / beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-...
TMPJ-00432 GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293 Cells
TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell res...
TMPY-02122 IFNGR2 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disea...
TMPJ-01143 MERTK/Mer Protein, Human, Recombinant (aa 1-323, His) Human HEK293 Cells
Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one...
TMPJ-00047 IL-31 Protein, Human, Recombinant Human E. coli
Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes...
STAT1 Protein, Human, Recombinant
TMPJ-00961
Species: Human
Expression System: E. coli
STAT1 Protein, Human, Recombinant (His & GST)
TMPY-02240
Species: Human
Expression System: Baculovirus Insect Cells
SCF Protein, Mouse, Recombinant
TMPJ-00166
Species: Mouse
Expression System: E. coli
FANCC Protein, Human, Recombinant (His & SUMO)
TMPH-01322
Species: Human
Expression System: E. coli
Erythropoietin Protein, Pig, Recombinant (His)
TMPH-03110
Species: Sus scrofa (Pig)
Expression System: P. pastoris (Yeast)
Erythropoietin Protein, Horse, Recombinant (hFc)
TMPH-00827
Species: Horse
Expression System: HEK293 Cells
Erythropoietin Protein, Cynomolgus, Recombinant (His & Myc)
TMPH-02426
Species: Cynomolgus
Expression System: HEK293 Cells
EPOR Protein, Rat, Recombinant (His & SUMO)
TMPH-03287
Species: Rat
Expression System: E. coli
Erythropoietin Protein, Horse, Recombinant (His & SUMO)
TMPH-00828
Species: Horse
Expression System: E. coli
Erythropoietin Protein, Pig, Recombinant (B2M & His)
TMPH-03111
Species: Sus scrofa (Pig)
Expression System: E. coli
Erythropoietin Protein, Cynomolgus, Recombinant (His & SUMO)
TMPH-02427
Species: Cynomolgus
Expression System: E. coli
IL-31R alpha Protein, Mouse, Recombinant (His)
TMPH-02740
Species: Mouse
Expression System: E. coli
IFNAR2 Protein, Mouse, Recombinant (His)
TMPH-02732
Species: Mouse
Expression System: P. pastoris (Yeast)
IL-9 Protein, Mouse, Recombinant (hFc)
TMPK-00026
Species: Mouse
Expression System: HEK293 Cells
IL-9 Protein, Cynomolgus, Recombinant (His)
TMPK-00568
Species: Cynomolgus
Expression System: HEK293 Cells
IL-26 Protein, Human, Recombinant (His)
TMPH-01559
Species: Human
Expression System: P. pastoris (Yeast)
IL-26 Protein, Human, Recombinant (His & Trx)
TMPH-01560
Species: Human
Expression System: E. coli
IFN gamma Protein, Goat, Recombinant (His & Myc)
TMPH-00775
Species: Goat
Expression System: E. coli
STAT2 Protein, Human, Recombinant (His)
TMPU-00003
Species: Human
Expression System: E. coli
IL-9 Protein, Human, Recombinant (hFc)
TMPK-00025
Species: Human
Expression System: HEK293 Cells
SCF Protein, Rat, Recombinant (His)
TMPJ-00894
Species: Rat
Expression System: E. coli
IFNAR1 Protein, Rhesus macaque, Recombinant (His)
TMPJ-00331
Species: Rhesus
Expression System: HEK293 Cells
GITR Ligand/TNFSF18 Protein, Cynomolgus, Recombinant (His)
TMPJ-00432
Species: Cynomolgus
Expression System: HEK293 Cells
IFNGR2 Protein, Mouse, Recombinant (His)
TMPY-02122
Species: Mouse
Expression System: HEK293 Cells
MERTK/Mer Protein, Human, Recombinant (aa 1-323, His)
TMPJ-01143
Species: Human
Expression System: HEK293 Cells
IL-31 Protein, Human, Recombinant
TMPJ-00047
Species: Human
Expression System: E. coli
Cat No. Product Name
L3700 JAK-STAT Compound Library

252 compounds
A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;

Libraries

JAK-STAT Compound Library
L3700
Compounds: 252
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