Powder: -20°C for 3 years | In solvent: -80°C for 1 year
C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, while exhibiting little effect against IFN-γ-stimulated HepG2 cellular STAT1 phosphorylation.
Description | C188 is a cell-permeable naphthol compound and a STAT3 inhibitor. C188 inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells by targeting STAT3 SH2 domain peptide-binding pocket, while exhibiting little effect against IFN-γ-stimulated HepG2 cellular STAT1 phosphorylation. |
Synonyms | Cpd188, STAT3-IN-C188, Cpd-188, C 188, C-188 |
Molecular Weight | 433.45 |
Formula | C19H15NO7S2 |
CAS No. | 823828-18-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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C188 823828-18-8 Cpd188 STAT3-IN-C188 Cpd-188 C 188 STAT3-IN-C-188 C-188 STAT3-IN-C 188 inhibitor inhibit