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Sophocarpine

Catalog No. T6677 CAS 6483-15-4

Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.

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Sophocarpine, CAS 6483-15-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 45.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 145.00
50 mg	In stock	$ 215.00
100 mg	In stock	$ 322.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98.67%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
In vitro	Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. [1] Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. [2] In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. [3]
In vivo	Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. [1] LD50: Mice 63.94 mg/kg (i.v.) [4]
Source	Natural Products > Fabaceae > Sophora

Molecular Weight	246.35
Formula	C15H22N2O
CAS No.	6483-15-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 49 mg/mL (198.9 mM)

H2O: 5 mg/mL(20.30 mM)

DMSO: 49 mg/mL (198.9 mM)

References and Literature

1. Liu XQ, et al. [Thymopolypeptides combined with matrine type alkaloids suppress HBV replication]. Zhongguo Zhong Yao Za Zhi. 2016 Apr;41(7):1275-1281. Chinese. 2. Zhang Y, et al. Sophocarpine and matrine inhibit the production of TNF-alpha and IL-6 in murine macrophages and prevent cachexia-related symptoms induced by colon26 adenocarcinoma in mice. Int Immunopharmacol. 2008 Dec 20;8(13-14):1767-72. 3. Song CY, et al. Sophocarpine alleviates hepatocyte steatosis through activating AMPK signaling pathway. Toxicol In Vitro. 2013 Apr;27(3):1065-71. 4. Gao Y, et al. Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-κB and MAPKs signaling pathways. Toxicol In Vitro. 2012 Feb;26(1):1-6.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Membrane Protein-targeted Compound Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Antidepressant Compound Library Anti-Viral Compound Library Human Metabolite Library RO5 Drug-like Natural Product Library Bioactive Compound Library

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Keywords

Sophocarpine 6483-15-4 Angiogenesis Immunology/Inflammation JAK/STAT signaling MAPK Neuroscience NF-Κb Stem Cells Tyrosine Kinase/Adaptors ERK p38 MAPK HER COX TLR NF-κB JNK STAT Apoptosis Influenza Virus PI3K Phosphoinositide 3-kinase Inhibitor Autophagy PKB Akt Protein kinase B inhibit inhibitor

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