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Nifuroxazide

Catalog No. T1563 CAS 965-52-6

Synonyms: Diarlidan, Nifuroxazid, Dicoferin

Nifuroxazide (Diarlidan) is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STAT1/3/5 transcription.

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Nifuroxazide, CAS 965-52-6

Pack Size	Availability	Price/USD
100 mg	In stock	$ 38.00
200 mg	In stock	$ 54.00
1 mL * 10 mM (in DMSO)	In stock	$ 47.00

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Purity: 99.87%

Purity: 99.2%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Nifuroxazide (Diarlidan) is an orally available and cell-permeable nitrofuran-based antidiarrheal agent. It has the inhibitory effect against the activation of cellular STAT1/3/5 transcription.

In vivo

Nifuroxazide does not affect the phosphorylation of Akt or MAPK. It inhibits the survival of myeloma cells by reducing the autophosphorylation of Jak kinases, thereby blocking the constitutive phosphorylation of STAT3, but has no effect on normal peripheral blood mononuclear cells. Nifuroxazide decreases the tyrosine phosphorylation of TYK2 and Jak, demonstrating selectivity towards TYK2 and Jak2 without impacting the tyrosine kinases of the EGF receptor or Src kinase. This effect is achieved through the reduction of Jak kinases' autophosphorylation, leading to the inhibition of constitutive phosphorylation of STAT3 in MM (multiple myeloma) cells and the downregulation of the STAT3 target gene, Mcl-1. Consequently, Nifuroxazide reduces the viability of primary myeloma cells and cell lines with activated STAT3 but does not affect normal peripheral blood mononuclear cells. It also blocks the survival signals provided by bone marrow stromal cells to myeloma cells. Compared to interactions with other cellular pathways, Nifuroxazide shows increased cytotoxicity when combined with the histone deacetylase inhibitor Trichostatin or the MEK inhibitor UO126, targeting STAT3.

Synonyms	Diarlidan, Nifuroxazid, Dicoferin
Molecular Weight	275.22
Formula	C12H9N3O5
CAS No.	965-52-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 51 mg/mL (185.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Nelson EA, et al. Blood, 2008, 112(13), 5095-5102.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Prostate Cancer Compound Library Anti-Bacterial Compound Library ReFRAME Related Library Cancer Cell Differentiation Compound Library FDA-Approved & Pharmacopeia Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nifuroxazide 965-52-6 JAK/STAT signaling Microbiology/Virology Stem Cells Antibacterial Antibiotic STAT Diarlidan Inhibitor Nifuroxazid Dicoferin Bacterial inhibit inhibitor

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