Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 77.00 | |
2 mg | In stock | $ 109.00 | |
5 mg | In stock | $ 170.00 | |
10 mg | In stock | $ 298.00 | |
25 mg | In stock | $ 491.00 | |
50 mg | In stock | $ 729.00 | |
100 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 198.00 |
Description | Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2). |
Targets&IC50 | JAK2:803 nM, JAK1:29 nM, Tyk2:1253 nM |
In vitro | Abrocitinib inhibits IFN-stimulated phosphorylation of STAT1 in human whole blood (HWB), IFNα-stimulated phosphorylation of STAT3, as well as pSTAT5 in CD34+ spiked into HWB (JAK2), with IC50s of 163, 189 nM, 7.178 μM, respectively. |
In vivo | In the rat adjuvant-induced arthritis model, Abrocitinib (5, 15, 50 mg/kg, p.o., daily for 7 days) significantly reduces paw swelling. |
Synonyms | PF-04965842 |
Molecular Weight | 323.41 |
Formula | C14H21N5O2S |
CAS No. | 1622902-68-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (371.05 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Abrocitinib 1622902-68-4 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK inhibit PF04965842 Inhibitor PF-04965842 Janus kinase PF 04965842 inhibitor