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Abrocitinib

Catalog No. TQ0037   CAS 1622902-68-4
Synonyms: PF-04965842

Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).

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Abrocitinib Chemical Structure
Abrocitinib, CAS 1622902-68-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 77.00
2 mg In stock $ 109.00
5 mg In stock $ 170.00
10 mg In stock $ 298.00
25 mg In stock $ 491.00
50 mg In stock $ 729.00
100 mg In stock $ 987.00
1 mL * 10 mM (in DMSO) In stock $ 198.00
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Purity: 99.91%
Purity: 99.05%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).
Targets&IC50 JAK2:803 nM, JAK1:29 nM, Tyk2:1253 nM
In vitro Abrocitinib inhibits IFN-stimulated phosphorylation of STAT1 in human whole blood (HWB), IFNα-stimulated phosphorylation of STAT3, as well as pSTAT5 in CD34+ spiked into HWB (JAK2), with IC50s of 163, 189 nM, 7.178 μM, respectively.
In vivo In the rat adjuvant-induced arthritis model, Abrocitinib (5, 15, 50 mg/kg, p.o., daily for 7 days) significantly reduces paw swelling.
Synonyms PF-04965842
Molecular Weight 323.41
Formula C14H21N5O2S
CAS No. 1622902-68-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (371.05 mM), sonification is recommended.

TargetMolReferences and Literature

1. Vazquez ML, et al. Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. J Med Chem. 2018 Feb 8;61(3):1130-1152.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Reprogramming Compound Library Drug Repurposing Compound Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Anti-Pancreatic Cancer Compound Library Approved Drug Library Anti-Obesity Compound Library

Related Products

Related compounds with same targets
FLLL32 Cerdulatinib hydrochloride Golidocitinib SAR-20347 Butyzamide NVP-BSK805 2HCl (1092499-93-8(free base)) JAK2-IN-7 TG101209

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Keywords

Abrocitinib 1622902-68-4 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK inhibit PF04965842 Inhibitor PF-04965842 Janus kinase PF 04965842 inhibitor

 

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