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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T78887 | ROS-IN-2 | Reactive Oxygen Species | |
ROS-IN-2 (compound 85), a seco-lupane triterpenoid derivative, inhibits reactive oxygen species (ROS) production and shields mitochondria from oxidative damage by curtailing the generation of oxidative stressors. It has ... | |||
T74671 | ROS kinases-IN-2 | ROS Kinase | |
ROS kinases-IN-2 is a potent ROS kinase inhibitor with an inhibition rate of 21.53% measured at 10 μM.ROS kinases-IN-2 has potential anticancer activity and can be used to study abnormal cell growth. | |||
T9560 | MAO-B-IN-2 | ||
MAO-B-IN-2 is a selective and competitive inhibitor of MAO-B and BChE with IC 50 values of 0.51 and 7.00 μM, respectively. MAO-B-IN-2 attenuates H2O2-induced cellular damage via good ROS scavenging property. | |||
T15433 | GSK2795039 | Apoptosis , Reactive Oxygen Species , ROS , NADPH | |
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays). | |||
T38404 | MJ33 lithium salt | ROS | |
MJ33 lithium salt is an inhibitor of NADPH oxidase type 2-mediated ROS generation, a fluorinated phospholipid analog that inhibits the phospholipase A2 (PLA2) activity of peroxiredoxin 6 (Prdx6), and is used in the study... | |||
T6S1373 | Casticin | Quercetagetin 3,6,7,4'-Tetramethyl Ether,Vitexicarpin | STAT |
1. Casticin (Vitexicarpin) can significantly reduce vascular inflammation, through inhibition of ROS-NF-κB pathway in vascular endothelial cells. 2. Casticin may become a potential leading drug in the therapy of prostate... | |||
T3008 | Lawsone methyl ether | 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone | Apoptosis , Antibacterial , Antifungal |
Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated that these s... | |||
T2915 | Bardoxolone | RTA 401,CDDO | Others , Nrf2 |
Bardoxolone (CDDO) is a synthetic oleanane triterpenoid that blocks the cellular synthesis of inducible nitric oxide synthase and inducible COX-2 in INF-γ-activated mouse macrophages with an IC50 value of 0.4 nM. By supp... | |||
T14021 | 20-HETE | 20-hydroxy Arachidonic Acid | Others |
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH ... | |||
T5S1331 | Herbacetin | c-Met/HGFR , Akt | |
1. Herbacetin induces apoptosis in HepG2 cells, by ROS and PI3K/Akt pathway. 2. Herbacetin suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation. | |||
T5S2283 | Sesamolin | p38 MAPK , Caspase , JNK | |
1. Sesamolin and Sesamin has neuroprotective effect. 2. Sesamolin protects microglia against H2O2-induced cell injury, by inhibiting of p38 MAPK and caspase-3 activation and ROS production. 3. Sesamolin and Sesamin can s... | |||
T4S1050 | Pristimerin | Celastrol methyl ester | NF-κB , Antibacterial |
1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell... | |||
T5S0045 | Isofraxidin | 6,8-Dimethoxyumbelliferone,Phytodolor | MMP , ERK , p38 MAPK , TLR , COX |
1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote... | |||
T2860 | Vanillyl Alcohol | 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol | Apoptosis , Others |
Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) possesses anti-angiogenic, anticonvulsive, anti-inflammatory, anti-oxidant, neuroprotective, and anti-nociceptive activities. Vanillyl alcohol can effectively inhibit ... | |||
T2S0618 | β-Elemonic Acid | 3-oxo Tirucallic Acid,Beta-Elemonic acid,3-Oxotirucallenoic Acid,Elemadienonic Acid | Apoptosis , Reactive Oxygen Species , COX |
β-Elemonic Acid (3-Oxotirucallenoic Acid) exhibits anti-inflammatory effects. Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are rel... | |||
T77579 | JC2-11 | IL Receptor , Dehydrogenase , ROS , Caspase , NOD-like Receptor (NLR) , AIM2 | |
JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen sp... | |||
T6S1699 | Shogaol | [6]-Shogaol,6-Shogaol | Lipoxygenase , Autophagy |
1. 6-Shogaol (6-Shogaol) has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduces the inflammatory response and protected the f... | |||
T6S0735 | Flavokawain B | Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone | Apoptosis , Others |
1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, in... | |||
T6S0139 | Neobavaisoflavone | Apoptosis , DNA/RNA Synthesis | |
1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si... | |||
T2563 | Acetyl-L-carnitine hydrochloride | Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride | Others , Endogenous Metabolite |
Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) is a nutritional supplement composed of the hydrochloride salt form of the acetylated form of the endogenously produced L-carnitine, with potential neur... |