Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 67.00 | |
5 mg | In stock | $ 163.00 | |
10 mg | In stock | $ 263.00 | |
25 mg | In stock | $ 447.00 | |
50 mg | In stock | $ 646.00 | |
100 mg | In stock | $ 888.00 | |
500 mg | In stock | $ 1,790.00 |
Description | 1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells. |
Source |
Synonyms | Flavokavain B, Flavokawin B, 2'-Hydroxy-4',6'-Dimethoxychalcone |
Molecular Weight | 284.31 |
Formula | C17H16O4 |
CAS No. | 1775-97-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 38 mg/mL(133.7 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
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Flavokawain B 1775-97-9 Apoptosis Others Flavokavain B inhibit Flavokawin B 2'-Hydroxy-4',6'-Dimethoxychalcone Inhibitor inhibitor