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Search Result

Search Results for " pad "

Targets

PAD

54

Compounds

8

Natural Products

10

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T35817 Photoswitchable PAD Inhibitor (technical grade)
Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity.1 Without ph...
T63284 PAD-IN-2
PAD-IN-2 is a potent inhibitor of pad4 with an IC50 value <1 μM and can be used to study autoimmune diseases and cancers such as rheumatoid arthritis, vasculitis, systemic lupus erythematosus, cutaneous lupus erythematos...
T39515 PAD2-IN-1 PAD2-IN-1
PAD2-IN-1, a benzimidazole-based derivative, is an efficacious and specific inhibitor of protein arginine deiminase 2 (PAD2). Demonstrating remarkable selectivity, PAD2-IN-1 exhibits a 95-fold higher affinity for PAD2 in...
T16564 PPADS tetrasodium P2X Receptor , Na+/Ca2+ Exchanger
PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/NMDA toxicity.PPADS tetrasodiuma in...
T7503 Upadacitinib ABT-494 JAK
Upadacitinib (ABT-494) (ABT-494) is a selective Janus kinase (JAK) 1 inhibitor, which is being studied for the treatment of several autoimmune disorders in the IC50 of 43 nM.
T2373 Vipadenant CEB-4520,BIIB-014 Adenosine Receptor
Vipadenant (CEB-4520)(BIIB-014) is an adenosine A2a antagonist with Ki of 1.3 nM; less potent for A1(Ki=69 nM).
T0113 Mebhydrolin napadisylate Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,Omeril,Diazoline 5-HT Receptor , AChR , Histamine Receptor
Mebhydrolin napadisylate (Incidal) is an antihistamine used to relieve allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
T76735 Mupadolimab CPI-006 CD73
Mupadolimab (CPI-006) is a humanized FC-γR binding deficient IgG1 anti-CD73 antibody with potential anticancer activity and activation of CD73POS B cells.
T16411 Otenzepad AF-DX 116 AChR
Otenzepad (AF-DX 116) is a selective antagonist of M2 mAChR with IC50s of 386 nM and 640 nM for rat heart and rabbit peripheral lung.
T16999 Tavapadon PF-6649751,CVL-751 Dopamine Receptor
Tavapadon (CVL-751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist.
T26641L Apadenoson TFA BAY 68-4986 TFA,Apadenoson TFA(250386-15-3 Free base),Discontinued TFA Adenosine Receptor
Apadenoson TFA is a potent adenosine A2A receptor (A2AR) agonist that can be used to improve survival in patients infected with SARS.
T22178L Spadin Acetate Spadin Acetate(1270083-24-3 Free base) Others
Spadin Acetate is a natural peptide derived from a propeptide released in blood. Spadin Acetate is able to block the TREK-1 channel activity. Spadin Acetate binds specifically to TREK-1 with an affinity of 10 nM.
T16427 Padsevonil UCB-0942 Others
Padsevonil is an effective antiepileptic compound.
T5167 Cebranopadol GRT6005 Opioid Receptor
Cebranopadol (GRT6005) is an analgesic NOP and opioid receptor agonist with Kis of 0.9 nM, 0.7 nM, 2.6 nM, 18 nM for human NOP, μ-opioid (MOP), κ-opioid (KOP) and δ-opioid (DOP) receptor, respectively.
TQ0125 Capadenoson BAY 68-4986 Adenosine Receptor
Capadenoson (BAY 68-4986) is a selective adenosine-A1 receptor agonist.
T19849L 2-PADQZ hydrochloride 2-PADQZ hydrochloride (60547-97-9 Free base) Antiviral , Influenza Virus
2-PADQZ hydrochloride shows antiviral activity and targets influenza A virus RNA promoter.
T71693 Nepadutant
Nepadutant is a useful organic compound for research related to life sciences. The catalog number is T71693 and the CAS number is 183747-35-5.
T69648 Inupadenant HCl
Inupadenant, also known as EOS-850, is a highly selective small molecule antagonist of the adenosine A2a receptor, in the adenosine triphosphate adenosine pathway, a key driver of immunosuppression in the tumor microenv...
T70857 Scopadulciol
Scopadulciol is and enzyme and proton pump inhibitor.
T40572 Lesogaberan napadisylate AZD-3355 napadisylate
Lesogaberan (AZD-3355) napadisylate is a potent and selective agonist of GABA B receptors, with an EC 50 of 8.6 nM for human recombinant GABA B receptors. It demonstrates an affinity (Ki) of 5.1 nM for rat GABA B recepto...
T32076 Hippadine
Hippadine is isolated from Crinum bulbs and has reproductive effect.
T26553 Aclatonium Napadisilate Acaltonium napadisilate
Aclatonium Napadisilate, a cholinergic agonist, has been shown to stimulates endocrine and exocrine pancreatic secretion.
T32722 Lexanopadol GRT-13106G,GRT6006,GRT 13106G,GRT-6006,GRT 6006,GRT13106G
Lexanopadol (GRT6006) is a potent ORL-1 agonist (opioid receptor-like-1), suitable for the treatment of moderate to severe chronic pain, including neuropathic pain.
T63601 PAD2-IN-1 hydrochloride
PAD2-IN-1 hydrochloride is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor with superior selectivity for PAD2 over PAD4 (95-fold) and PAD3 (79-fold), and is a benzimidazole-based derivative.
T126544 3-O-Acetylpadmatin
3-O-Acetylpadmatin is a useful organic compound for research related to life sciences. The catalog number is T126544 and the CAS number is 100595-93-5.
T81604 Opadotina
Opadotina, a small-molecule anvatabart opadotin, exhibits antineoplastic activity [1].
T24995 Abediterol napadisylate LAS100977 napadisylate
Abediterol napadisylate is a novel long-acting β2-agonist in persistent asthma that is efficacy, safe, and tolerable.
T79638 Lepadin E Glutathione Peroxidase
Lepadin E, a notably cytotoxic compound, effectively stimulates ferroptosis via the canonical p53-SLC7A11-GPX4 pathway. By elevating p53 and repressing SLC7A11 and GPX4 expression, it heightens ROS and lipid peroxidation...
T79276 PAD4-IN-2
PAD4-IN-2 (compound 5i) is a PAD4 inhibitor with an IC50 value of 1.94 μM, shown to suppress tumor growth in mice through specific inhibition of the PAD4-H3cit-NETs pathway in neutrophils [1].
T79639 Lepadin H Ferroptosis
Lepadin H, a marine alkaloid and ferroptosis inducer, exhibits significant cytotoxicity by promoting p53 expression, escalating ROS production, and enhancing lipid peroxidation. It simultaneously decreases SLC7A11 and GP...
T37014 Inupadenant
Inupadenant is an orally active, highly selective A2A receptor antagonist. Inupadenant is not brain-penetrant. Inupadenant has potent anti-tumor activity[1]. [1]. Laurence Buisseret, et al. Phase 1 trial of the adenosine...
T7503L Upadacitinib tartrate ABT 494,ABT-494,ABT494
Upadacitinib is a potent and selective JAK inhibitor. Upadacitinib is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. Upadacitinib demonstrates efficacy in...
T19849 2-PADQZ 2PADQZ,2-PADQZ
DPQ is an antiviral compound. DPQ has also been shown to bind to a widened RNA major groove at the internal loop. DPQ acts against the H1N1 and H3N2 strains of influenza A as well as influenza B.
T33793 Olpadronic acid Me2 APD,Me2-APD,Me2APD
Olpadronic acid is a biochemical.
T10749 Cebranopadol ((1α,4α)stereoisomer) GRT6005 (1α,4α)stereoisomer Others
Cebranopadol ((1α,4α)stereoisomer) is a stereoisomer of cebranopadol which is a potent ORL-1 agonist.
T75944 Spadin TFA
Spadin TFA, a natural peptide originating from a propeptide in blood, acts as a powerful TREK-1 channel inhibitor with an IC 50 of 10 nM. It boosts dorsal raphe nucleus 5-HT neurotransmission in mice, activates hippocamp...
T34058 Phyllospadine
Phyllospadine is a natural flavonoidal alkaloid from the sea-grass Phyllosphadix iwatensis.
T20599 Padimate O Escalol 507,Eusolex 6007,Arlatone UVB
Padimate O, a UVB absorber, is a major ingredient in sunscreens.
T35906 Padanamide A
Padanamide A is a bacterial metabolite originally isolated from a marine Streptomyces species. It is active against five strains of P. falciparum (EC50s = 160-340 nM), is not cytotoxic to HEK293 or HepG2 human cell lines...
T33863 Padimate A
Padimate A is a sunscreen ingredient.
T26641 Apadenoson ATL 146e,BMS 068645,ATL146e,BMS-068645,ATL-146e,BMS068645
Apadenoson is a potent Adenosine A2 receptor agonist with inhibitory effects on Adenosine A3 receptors with an IC of 45 nM. Apadenoson has anti-inflammatory activity and can be used to study neurological diseases.
T19356 HTBA Others
HTBA is a low-cost enzymatic paper-based analytical device (enz-PAD) for determining urine creatinine.
T9828 N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide PAD
N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide is a racemic form of Cl-amidine (S enantiomer). Cl-amidine is an orally active peptidylarginine deminase (PAD) inhibitor.
T10831L Cl-amidine hydrochloride Apoptosis , PAD
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro ca...
T20982 Sodium 3-nitrobenzenesulfonate Others
Sodium 3-nitrobenzenesulfonate is a mild oxidant. Sodium 3-nitrobenzenesulfonate can protect the shade when fabrics are printed or steamed in pad dyeing and counteract the effect of reducing substances.
T4978 Sarpogrelate hydrochloride MCI-9042 5-HT Receptor
Sarpogrelate hydrochloride (MCI-9042) , a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recepter Sarpogrelate is a drug which acts as an antagonist at ...
T10482L BB-Cl-Amidine hydrochloride BB-Cl-Amidine hydrochloride (1802637-39-3 free base) Others
BB-Cl-Amidine hydrochloride is an inhibitor of peptidylarginine deminase (PAD) [1].
T36107 YW3-56 YW3-56
YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4. Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-f...
T10831 Cl-amidine Others
Cl-amidine is an orally active inhibitor of peptidyl arginine deminase (PAD) (IC50s: 0.8 μM, 6.2 μM, and 5.9 μM for PAD1, PAD3, and PAD4). Cl-amidine induces apoptosis in cancer cells.
T10831L2 Cl-amidine TFA Others
Cl-amidine TFA is an orally active inhibitor of peptidyl arginine deminase (PAD) (IC50s: 0.8 μM, 6.2 μM, and 5.9 μM for PAD1, PAD3, and PAD4). Cl-amidine induces apoptosis in cancer cells.

Compounds

Photoswitchable PAD Inhibitor (technical grade)
T35817
Synonym:
Target:
PAD-IN-2
T63284
Synonym:
Target:
PAD2-IN-1
T39515
Synonym: PAD2-IN-1
Target:
PPADS tetrasodium
T16564
Synonym:
Target: P2X Receptor, Na+/Ca2+ Exchanger
Upadacitinib
T7503
Synonym: ABT-494
Target: JAK
Vipadenant
T2373
Synonym: CEB-4520,BIIB-014
Target: Adenosine Receptor
Mebhydrolin napadisylate
T0113
Synonym: Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,Omeril,Diazoline
Target: 5-HT Receptor, AChR, Histamine Receptor
Mupadolimab
T76735
Synonym: CPI-006
Target: CD73
Otenzepad
T16411
Synonym: AF-DX 116
Target: AChR
Tavapadon
T16999
Synonym: PF-6649751,CVL-751
Target: Dopamine Receptor
Apadenoson TFA
T26641L
Synonym: BAY 68-4986 TFA,Apadenoson TFA(250386-15-3 Free base),Discontinued TFA
Target: Adenosine Receptor
Spadin Acetate
T22178L
Synonym: Spadin Acetate(1270083-24-3 Free base)
Target: Others
Padsevonil
T16427
Synonym: UCB-0942
Target: Others
Cebranopadol
T5167
Synonym: GRT6005
Target: Opioid Receptor
Capadenoson
TQ0125
Synonym: BAY 68-4986
Target: Adenosine Receptor
2-PADQZ hydrochloride
T19849L
Synonym: 2-PADQZ hydrochloride (60547-97-9 Free base)
Target: Antiviral, Influenza Virus
Nepadutant
T71693
Synonym:
Target:
Inupadenant HCl
T69648
Synonym:
Target:
Scopadulciol
T70857
Synonym:
Target:
Lesogaberan napadisylate
T40572
Synonym: AZD-3355 napadisylate
Target:
Hippadine
T32076
Synonym:
Target:
Aclatonium Napadisilate
T26553
Synonym: Acaltonium napadisilate
Target:
Lexanopadol
T32722
Synonym: GRT-13106G,GRT6006,GRT 13106G,GRT-6006,GRT 6006,GRT13106G
Target:
PAD2-IN-1 hydrochloride
T63601
Synonym:
Target:
3-O-Acetylpadmatin
T126544
Synonym:
Target:
Opadotina
T81604
Synonym:
Target:
Abediterol napadisylate
T24995
Synonym: LAS100977 napadisylate
Target:
Lepadin E
T79638
Synonym:
Target: Glutathione Peroxidase
PAD4-IN-2
T79276
Synonym:
Target:
Lepadin H
T79639
Synonym:
Target: Ferroptosis
Inupadenant
T37014
Synonym:
Target:
Upadacitinib tartrate
T7503L
Synonym: ABT 494,ABT-494,ABT494
Target:
2-PADQZ
T19849
Synonym: 2PADQZ,2-PADQZ
Target:
Olpadronic acid
T33793
Synonym: Me2 APD,Me2-APD,Me2APD
Target:
Cebranopadol ((1α,4α)stereoisomer)
T10749
Synonym: GRT6005 (1α,4α)stereoisomer
Target: Others
Spadin TFA
T75944
Synonym:
Target:
Phyllospadine
T34058
Synonym:
Target:
Padimate O
T20599
Synonym: Escalol 507,Eusolex 6007,Arlatone UVB
Target:
Padanamide A
T35906
Synonym:
Target:
Padimate A
T33863
Synonym:
Target:
Apadenoson
T26641
Synonym: ATL 146e,BMS 068645,ATL146e,BMS-068645,ATL-146e,BMS068645
Target:
HTBA
T19356
Synonym:
Target: Others
N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide
T9828
Synonym:
Target: PAD
Cl-amidine hydrochloride
T10831L
Synonym:
Target: Apoptosis, PAD
Sodium 3-nitrobenzenesulfonate
T20982
Synonym:
Target: Others
Sarpogrelate hydrochloride
T4978
Synonym: MCI-9042
Target: 5-HT Receptor
BB-Cl-Amidine hydrochloride
T10482L
Synonym: BB-Cl-Amidine hydrochloride (1802637-39-3 free base)
Target: Others
YW3-56
T36107
Synonym: YW3-56
Target:
Cl-amidine
T10831
Synonym:
Target: Others
Cl-amidine TFA
T10831L2
Synonym:
Target: Others
1 2
Cat No. Product Name Synonyms Targets
TN2033 Padmatin Blumeatin C Others
Padmatin (Blumeatin C) is a component of the heartwood of Prunus puddum.
TN4847 Pterocarpadiol A Others
Pterocarpadiol A is a kind of very rare 6a,11b-dihydroxypterocarpan, and its presence as a marker may be helpful in chemotaxonomical classification.
TN4850 Pterocarpadiol D Others
Pterocarpadiol D is a kind of very rare 6a,11b-dihydroxypterocarpan, and its presence as a marker may be helpful in chemotaxonomical classification.
TN4848 Pterocarpadiol B Others
Pterocarpadiol B is a kind of very rare 6a,11b-dihydroxypterocarpan, and its presence as a marker may be helpful in chemotaxonomical classification.
T83360 3-epi-Padmatin
3-epi-Padmatin, a natural product extractable from Inula graveolens, exhibits potent biological activities [1].
TN4849 Pterocarpadiol C Others
Pterocarpadiol C is a kind of very rare 6a,11b-dihydroxypterocarpan, and its presence as a marker may be helpful in chemotaxonomical classification.
T2205 Acefylline Theophylline-7-acetic acid,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid TNF , PAD , PKA , HDAC , PDE , Adenosine Receptor
Acefylline (Theophylline-7-acetic acid), a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation Etanautine to help...
T16946 Streptonigrin Bruneomycin Others
Streptonigrin is a natural product produced by Streptomyces flocculus, has both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor (IC50s: 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0...

Natural Products

Padmatin
TN2033
Synonym: Blumeatin C
Target: Others
Pterocarpadiol A
TN4847
Synonym:
Target: Others
Pterocarpadiol D
TN4850
Synonym:
Target: Others
Pterocarpadiol B
TN4848
Synonym:
Target: Others
3-epi-Padmatin
T83360
Synonym:
Target:
Pterocarpadiol C
TN4849
Synonym:
Target: Others
Acefylline
T2205
Synonym: Theophylline-7-acetic acid,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid
Target: TNF, PAD, PKA, HDAC, PDE, Adenosine Receptor
Streptonigrin
T16946
Synonym: Bruneomycin
Target: Others

Recombinant Proteins

Species：
Human (6)
Cynomolgus (2)
Porphyromonas gingivalis (1)
Shigella flexneri (1)
Expression System：
E. coli (7)
Baculovirus Insect Cells (1)
HEK293 Cells (1)
P. pastoris (Yeast) (1)
Tag：
N-His (4)
N-6xHis (3)
N-10xHis, C-Myc (1)
N-10xHis-SUMO, C-Myc (1)
N-6xHis-SUMO (1)
Cat No. Product Name Species Expression System
TMPY-00021 PADI4 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase f...
TMPK-00501 PADI4 Protein, Cynomolgus, Recombinant (His) Cynomolgus E. coli
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide anti...
TMPK-00502 PADI4 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated Cynomolgus E. coli
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide anti...
TMPK-01238 PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated Human E. coli
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide anti...
TMPH-03158 PAD Protein, Porphyromonas gingivalis, Recombinant (His) Porphyromonas gingivalis E. coli
Deiminates the guanidino group of C-terminal arginine residues on a variety of peptides, including the vasoregulatory peptide-hormone bradykinin, to yield ammonia and a citrulline residue. May promote the growth of the p...
TMPJ-00532 PADI4 Protein, Human, Recombinant (E. coli, His) Human E. coli
Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyz...
TMPH-01966 PADI2 Protein, Human, Recombinant (His & SUMO) Human E. coli
PADI2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-03507 IpaD Protein, Shigella flexneri, Recombinant (His & Myc & SUMO) Shigella flexneri E. coli
Required for bacterial invasion of host cells. Controls IpaB and IpaC secretion, and the efficiency with which they are physically inserted into target cell membranes. These proteins are exported via TTSS to form a pore ...
TMPH-01965 PADI2 Protein, Human, Recombinant (His & Myc) Human HEK293 Cells
PADI2 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
TMPH-01967 PADI3 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
PADI3 Protein, Human, Recombinant (His) is expressed in Yeast.
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