Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Otenzepad (AF-DX 116) is a selective antagonist of M2 mAChR with IC50s of 386 nM and 640 nM for rat heart and rabbit peripheral lung.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 76.00 | |
10 mg | In stock | $ 133.00 | |
25 mg | In stock | $ 283.00 | |
50 mg | In stock | $ 455.00 | |
100 mg | In stock | $ 672.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | Otenzepad (AF-DX 116) is a selective antagonist of M2 mAChR with IC50s of 386 nM and 640 nM for rat heart and rabbit peripheral lung. |
Targets&IC50 | M2 mAChR (rabbit peripheral lung):640 nM, M2 mAChR (rat heart):386 nM |
In vivo | In rats, Otenzepad (2 mg/kg; s.c.) significantly improved retention relative to vehicle controls. Otenzepad (0.5, 1 mg/kg; s.c.) significantly improved win-stay acquisition[1]. In mice, Otenzepad (0.3, 1.0, or 3.0 mg/kg, i.p.) reverses the effects of insulin on memory and potentiates the effects of glucose[2]. |
Synonyms | AF-DX 116 |
Molecular Weight | 421.54 |
Formula | C24H31N5O2 |
CAS No. | 102394-31-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 24 mg/mL (56.93 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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Otenzepad 102394-31-0 Neuroscience AChR Muscarinic acetylcholine receptor Inhibitor AF-DX 116 mAChR inhibit AF-DX116 memory AF-DX-116 inhibitor