Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tavapadon (CVL-751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 74.00 | |
5 mg | In stock | $ 178.00 | |
10 mg | In stock | $ 289.00 | |
25 mg | In stock | $ 528.00 | |
50 mg | In stock | $ 743.00 | |
100 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 198.00 |
Description | Tavapadon (CVL-751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist. |
In vivo | Administered subcutaneously to captive-bred macaques, Tavapadon at a dose of 0.1 mg/kg results in a mean maximal unbound plasma concentration of 8 nM, with peak levels reached 3 hours post-administration. At lower doses (0.02 and 0.04 mg/kg; s.c.), only the 0.04 mg/kg dosage significantly increases locomotor activity, while the 0.02 mg/kg dosage exhibits minimal to no impact. Furthermore, a 0.04 mg/kg dose of Tavapadon not only enhances locomotor activity but also notably improves parkinsonian disability scores, with maximum benefits observed at 110 minutes after administration. Higher doses of Tavapadon (0.1 and 0.15 mg/kg; s.c.) demonstrate a statistically significant improvement in locomotor activity compared to a vehicle control [1]. |
Synonyms | PF-6649751, CVL-751 |
Molecular Weight | 391.34 |
Formula | C19H16F3N3O3 |
CAS No. | 1643489-24-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (153.32 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tavapadon 1643489-24-0 GPCR/G Protein Neuroscience Dopamine Receptor PF 6649751 CVL 751 inhibit PF 06649751 Inhibitor PF-06649751 PF06649751 PF6649751 CVL751 PF-6649751 CVL-751 inhibitor