Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 5 days | $ 1,050.00 | |
500 μg | 5 days | $ 4,200.00 | |
1 mg | 5 days | $ 6,990.00 |
Description | Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes. |
Species | Human |
Expression System | E. coli |
Tag | N-His |
Accession Number | Q9UM07 |
Synonyms | PDI5, Protein-arginine deiminase type-4, HL-60, PAD4, HL-60 PAD, PAD, HL60 PAD, PADI5 |
Construction | Recombinant Biotinylated Human PADI4 Protein(Primary Amine Labeling) is expressed from E.coli with His tag at the N-Terminus. It contains Met1-Pro663.[Accession |Q9UM07] |
Protein Purity | > 95% as determined by Tris-Bis PAGE |
Molecular Weight | The protein has a predicted MW of 76.6 kDa same as Tris-Bis PAGE result. |
Endotoxin | Less than 1EU per μg by the LAL method. |
Formulation | Supplied as 0.22μm filtered solution in LTSB. |
Stability & Storage |
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes. |
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PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated PDI-5 PDI5 PAD-4 Protein-arginine deiminase type-4 HL 60 HL-60 PAD4 HL-60 PAD PAD HL60 PAD PAD 4 PADI-5 HL60 PADI 5 PADI5 PDI 5 recombinant recombinant-proteins proteins protein