PADI4 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated

Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes.

Pack Size	Availability	Price/USD
100 μg	5 days	$ 1,050.00
500 μg	5 days	$ 4,200.00
1 mg	5 days	$ 6,990.00

Pack Size

Availability

Price/USD

Quantity

100 μg

5 days

$ 1,050.00

500 μg

5 days

$ 4,200.00

1 mg

5 days

$ 6,990.00

Description

Species	Cynomolgus
Expression System	E. coli
Tag	N-His
Accession Number	A0A2K5USI5
Synonyms	PDI5, HL-60, PAD, PADI5, Protein-arginine deiminase type-4, HL60 PAD, PAD4, HL-60 PAD
Construction	Recombinant Biotinylated Cynomolgus PADI4 Protein (Primary Amine Labeling) is expressed from E.coli with His tag at the N-Terminus. It contains Met1-Pro663.[Accession \|A0A2K5USI5]
Protein Purity	> 95% as determined by Tris-Bis PAGE
Molecular Weight	The protein has a predicted MW of 76.6 kDa same as Tris-Bis PAGE result.

Endotoxin	Less than 1EU per μg by the LAL method.
Formulation	Supplied as 0.22μm filtered solution in 20mM Tris, 500mM NaCl, 10% Glycerol, 0.5mM TCEP, 1mM EDTA (pH 8.0).
Stability & Storage	Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes.