nvp-2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T16363	NVP-2		Apoptosis , CDK
	NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CD...		Apoptosis , CDK
T1918	NVP-TAE 226	TAE226	Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
	NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK.		Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
TQ0231	NVP-CGM097	CGM097	Mdm2 , E1/E2/E3 Enzyme
	NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).		Mdm2 , E1/E2/E3 Enzyme
T5555	Siremadlin	NVP-HDM 201	E1/E2/E3 Enzyme
	Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.		E1/E2/E3 Enzyme
T1502	Vildagliptin	NVP-LAF 237,LAF237	Apoptosis , Ferroptosis , Proteasome , DPP-4
	Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolit...		Apoptosis , Ferroptosis , Proteasome , DPP-4
T2235	Dactolisib	BEZ235,NVP-BEZ235	ATM/ATR , PI3K , mTOR , Autophagy
	Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).		ATM/ATR , PI3K , mTOR , Autophagy
T2251	NVP-TAE 684	TAE684	Apoptosis , ALK
	NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).		Apoptosis , ALK
T33763	NVP CXCR2 20	NVP-CXCR2 20,NVP CXCR2-20,NVP CXCR220
	NVP CXCR2 20 is an effective selective CXCR2 antagonist (IC50 = 40 nM) with oral bioavailability.
T5049	NVP-BSK805	NVP-BSK805 2HCl,BSK 805	Tyrosine Kinases , JAK
	NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.		Tyrosine Kinases , JAK
T3463	NVP-ACC789	ACC-789,ZK202650	VEGFR , PDGFR
	ACC-789 (NVP-ACC789 (ZK202650); ZK-202650) is an effective, specific and orally active inhibitor of the VEGF receptor tyrosine kinases.		VEGFR , PDGFR
T1975	Infigratinib	BGJ-398,NVP-BGJ398	Apoptosis , FGFR
	Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 and VEGFR2.		Apoptosis , FGFR
T1933	NVP 231		Apoptosis , ERK
	NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.		Apoptosis , ERK
T2116	AEE788	NVP-AEE 788	Apoptosis , EGFR , c-Fms , FLT , Bcr-Abl
	AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.		Apoptosis , EGFR , c-Fms , FLT , Bcr-Abl
T6079	NVP-ADW742	ADW742,ADW,GSK 552602A	Apoptosis , IGF-1R
	NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.		Apoptosis , IGF-1R
T25894	NVP-AAD777	AAD-777,NVP-AAD-777,NVP AAD 777
	NVP-AAD777 is a specific VEGFR-2 inhibitor.
T74717	12-Hydroxynevirapine
	12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP), a significant oxidative metabolite of Nevirapine—an antiviral drug used for HIV-1 infections known for potential idiosyncratic hepatotoxicity and skin rashes—undergoes bi...