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NVP-BSK805
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Catalog No. T5049Cas No. 1092499-93-8
NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.
NVP-BSK805
😃Good
Catalog No. T5049Cas No. 1092499-93-8
NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $57 | 7-10 days | |
| 5 mg | $133 | 7-10 days | |
| 10 mg | $220 | 7-10 days | |
| 25 mg | $432 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor. |
| Targets&IC50 | JAK1 JH1:31.63 nM, FL JAK2 (V617F):0.56 nM, TYK2 JH1:10.76 nM, JAK3 JH1:18.68 nM, JAK2 JH1:0.48 nM, FL JAK2 (WT):0.58 nM |
| In vitro | GI50 of <100 nM. NVP-BSK805 blocks the STAT5 phosphorylation at ≥100 nM concentrations, and shows a bias for JAK2 over JAK1 and JAK3 inhibition in the JAK2V617F-mutant cell lines. NVP-BSK805 (5 μM) improves P-gp inhibitory activity. NVP-BSK805 increases sensitization of drug-resistant KBV20C cancer cells to VIC treatment at 10 μM, and such an effect is more effective than a 5 μM dose. |
| In vivo | NVP-BSK805 (150 mg/kg, p.o.) blocks STAT5 phosphorylation, splenomegaly, and leukemic cell spreading in a Ba/F3 JAK2V617F cell-driven mouse model. NVP-BSK805 (50, 75, and 100 mg/kg, p.o.) also suppresses rhEpo-mediated polycythemia and splenomegaly in BALB/c mice. |
| Molecular Weight | 490.55 |
| Formula | C27H28F2N6O |
| Cas No. | 1092499-93-8 |
| Smiles | Cl.Cl.Fc1cc(cc(F)c1CN1CCOCC1)-c1cccc2ncc(nc12)-c1cnn(c1)C1CCNCC1 |
| Relative Density. | 1.4 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mM, Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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