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Catalog No. T5049   CAS 1092499-93-8
Synonyms: BSK 805, NVP-BSK805 2HCl

NVP-BSK805 is an ATP-competitive JAK2 inhibitor.

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NVP-BSK805, CAS 1092499-93-8
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description NVP-BSK805 is an ATP-competitive JAK2 inhibitor.
Targets&IC50 JAK1 JH1:31.63 nM, FL JAK2 V617F:0.56 nM, TYK2 JH1:10.76 nM, JAK3 JH1:18.68 nM, JAK2 JH1:0.48 nM, FL JAK2 wt:0.58 nM
In vitro GI50 of <100 nM. NVP-BSK805 blocks the STAT5 phosphorylation at ≥100 nM concentrations, and shows a bias for JAK2 over JAK1 and JAK3 inhibition in the JAK2V617F-mutant cell lines. NVP-BSK805 (5 μM) improves P-gp inhibitory activity. NVP-BSK805 increases sensitization of drug-resistant KBV20C cancer cells to VIC treatment at 10 μM, and such an effect is more effective than a 5 μM dose.
In vivo NVP-BSK805 (150 mg/kg, p.o.) blocks STAT5 phosphorylation, splenomegaly, and leukemic cell spreading in a Ba/F3 JAK2V617F cell-driven mouse model. NVP-BSK805 (50, 75, and 100 mg/kg, p.o.) also suppresses rhEpo-mediated polycythemia and splenomegaly in BALB/c mice.
Synonyms BSK 805, NVP-BSK805 2HCl
Molecular Weight 490.54
Formula C27H28F2N6O
CAS No. 1092499-93-8


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Cheon JH, et al. The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine. Biochem Biophys Res Commun. 2017 Sep 2;490(4):1176-1182. 2. Rubert J, et al. BMC Cancer, 2011, Jan(19), 11-24. 3. Baffert F, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55.

Dose Conversion

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box


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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box


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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.


NVP-BSK805 1092499-93-8 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells Tyrosine Kinase/Adaptors Tyrosine Kinases JAK Inhibitor ATP-competitive NVP-BSK-805 Janus kinase NVP BSK805 JAK1 inhibit NVPBSK805 BSK 805 homology TYK2 JAK3 NVP-BSK805 2HCl JH1 JAK2 inhibitor