Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, <16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
2 mg | In stock | $ 68.00 | |
5 mg | In stock | $ 107.00 | |
10 mg | In stock | $ 178.00 | |
25 mg | In stock | $ 321.00 | |
50 mg | In stock | $ 591.00 | |
100 mg | In stock | $ 843.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 108.00 |
Description | NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit. |
Targets&IC50 | IGF-1R:0.17 μM |
In vitro | CRT0044876 potently inhibits the AP endonuclease, 3'-phosphodiesterase and 3'-phosphatase activities of APE1, and exhibits the selectivity for the inhibition of exonuclease III family. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds with an accumulation of unrepaired AP sites. [1] CRT0044876, by inhibition of the BER pathway increases oxidative DNA damage temporally related to increased intracellular reactive oxygen species in an acidic tumor microenvironment, and thus results in cell cycle arrests and increased DNA double strand breaks, leading to cell death. [2] |
Synonyms | ADW742, ADW, GSK 552602A |
Molecular Weight | 453.58 |
Formula | C28H31N5O |
CAS No. | 475488-23-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 10 mg/mL (22.04 mM), Heating is recommended.
Ethanol: 3 mg/mL (6.61 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NVP-ADW742 475488-23-4 Apoptosis Tyrosine Kinase/Adaptors IGF-1R inhibit Inhibitor hematologic multiple NVP-ADW-742 NVP ADW742 NVPADW742 ADW742 ADW 742 antiproliferative tumor Insulin Receptor InsR proapoptotic myeloma ADW-742 orally malignancies NVP-ADW 742 solid pleiotropic ADW GSK 552602A inhibitor