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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13799 | NQO1 substrate | NADPH | |
NQO1 substrate is a highly potent NQO1 substrate with potential antitumor activity for leukemia research. | |||
T16342 | KL1333 | NQO1 activator 1 | NADPH , Mitochondrial Metabolism |
KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 ... | |||
T6798 | Tretazicar | 5-Aziridino-2,4-dinitrobenzamide,CB1954,NSC 115829 | DNA Alkylator/Crosslinker , DNA Alkylation |
CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cy... | |||
T0153 | Oltipraz | NSC 347901,RP 35972 | HIF/HIF Prolyl-Hydroxylase , HIV Protease , Reverse Transcriptase , Nrf2 , HIF |
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin... | |||
T5S1805 | 5,7-Dihydroxychromone | 5,7-Dihydroxy-4H-Chromen-4-One | Others , Virus Protease , PARP , Caspase , Nrf2 |
1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5,7-Dihydroxychromone exerts neuroprotective effect agai... | |||
T6S2099 | Geraniin | Antioxidant , TNF | |
1. Geraniin has a protective effect against OVX-induced rat osteoporosis. 2. Geraniin has cytotoxic activity towards cancer cells in vitro and in vivo. 3. Geraniin exerts inhibitory effects on osteoclast differentiation ... | |||
TN2272 | Tigloylgomisin H | Nrf2 | |
Tigloylgomisin H represents a potential liver cancer prevention agent, it can significantly induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells, it functions as a novel monofunctional inducer ... | |||
T0809 | Dicoumarol | Dicumarol | Dehydrogenase , NADPH , PDK |
Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; t... | |||
T38901 | Isobutyl-deoxynyboquinone | IB-DNQ,Isobutyl-deoxynyboquinone | |
Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H: quinone oxidoreductase (NQO1) and is utilized in anticancer research. | |||
T61186 | Antitumor agent-57 | ||
Antitumor agent-57 (Compound 3o) is a potent NQO1-directed antitumor compound. It effectively inhibits tumor cell growth, induces ROS generation, and promotes cell apoptosis [1]. | |||
T81984 | Keap1-Nrf2-IN-10 | ||
Keap1-Nrf2-IN-10 (compound 15) is a potent inducer of NQO1 and efficaciously mitigates oxidative stress in gamma-irradiated mice by reducing MDA and ROS levels, as well as NQO1 in the liver, which enhances the survival r... | |||
T82305 | Glucoarabin | ||
Glucoarabin, a bioactive glucosinolate, upregulates the phase II detoxification enzyme quinone reductase (NQO1) in Hepa1c1c7 cells when hydrolyzed (hGSL 9), without affecting cytochrome P450 (CYP) 1A1 activity [1]. | |||
T36358 | Diminutol | ||
Diminutol is a cell-permeable purine derivative that inhibits the NADP-dependent oxidoreductase, NQO1 (Ki = 1.72 μM), to destabilize microtubules and disrupt mitosis. At 50 μM, it directly affects tubulin polymerization ... | |||
TN1543 | Cynaropicrin | IL Receptor , Others , TNF | |
Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential anticancer agent against some leukocyte cancer cells such as... | |||
T64057 | Nampt-IN-8 | ||
Nampt-IN-8 is a NAMPT inhibitor (IC50: 0.183 μM) and a good substrate for NQO1. Nampt-IN-8 induces reactive oxygen species (ROS) production and apoptosis. | |||
T83001 | Antitumor agent-67 | ||
Antitumor agent-67 (compound 3), a potent antitumor agent, exhibits highly selective toxicity toward cancer cells while sparing normal cells. This compound can be activated by NQO1 to effectively release podophyllotoxin,... | |||
TN3806 | Dehydroglyasperin C | ERK , IκB/IKK , p38 MAPK , TNF , NF-κB , Akt , COX , PI3K , NADPH , DNA/RNA Synthesis , Nrf2 , JNK , Autophagy | |
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protectiv... |