41
14
15
1
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4671 | BN82002 | CDC25 Phosphatase Inhibitor I | Phosphatase |
BN82002 (CDC25 Phosphatase Inhibitor I) is a synthetic inhibitor of CDC25 phophatases | |||
T7610 | GW284543 | UNC10225170 | MEK |
GW284543 (UNC10225170) is a selective inhibitor of MEK5 . | |||
T11898 | LXH254 | Raf | |
LXH254 is a potent C-Raf and B-Raf inhibitor. | |||
T8369 | Adagrasib | MRTX849 | Ras |
Adagrasib (MRTX849) is an orally active and selective covalent inhibitor of KRAS G12C. Adagrasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Adagrasib ... | |||
T21428 | Mianserin | Lantanon,Lumin,Norval,Lerivon,Depnon | Histamine Receptor |
Mianserin, an H1 receptor reverse agonist, is a psychoactive compound in the tetracyclic antidepressant (TeCA) treatment family. Mianserin has antidepressant, antianxiety, antiemetic, hypotrophic, hypnotic and antihistam... | |||
T64129 | MAX-40279 hemiadipate | ||
MAX-40279 hemiadipate is a potent, dual FLT3 kinase and FGFR kinase inhibitor. MAX-40279 hemiadipate has shown investigational potential in acute myeloid leukaemia (AML). | |||
T125365 | Cimiacerin B | ||
Cimiacerin B is a useful organic compound for research related to life sciences. The catalog number is T125365 and the CAS number is 210643-85-9. | |||
T72098 | Eleven-Nineteen-Leukemia Protein IN-3 | Epigenetic Reader Domain | |
Eleven-Nineteen-Leukemia Protein IN-3, an orally active ENL YEATS domain inhibitor, exhibits potent activity with an IC50 of 15.4 nM. It downregulates MYC expression via ENL in cells and enhances ENL protein's thermal st... | |||
T19969 | Cymiazole | CGA50439,CGA 50439,BRN 1213211,CGA-50439,BRN1213211,BRN-1213211 | |
Cymiazole is an agent of biochemical. | |||
T72096 | Eleven-Nineteen-Leukemia Protein IN-1 | Epigenetic Reader Domain | |
Eleven-Nineteen-Leukemia Protein IN-1 is a potent inhibitor of the ENL YEATS domain, exhibiting an IC50 of 14.5 nM. It binds to the ENL protein, consequently increasing its thermal stability in vitro [1]. | |||
T13573 | Arrhythmias-Targeting Compound 1 | Others | |
Arrhythmias-Targeting Compound 1 is a compound. It is used in the research of arrhythmias. | |||
T60906 | Miaosporone A | ||
Miaosporone A is an angucyclic quinone which shows cytotoxic activities against both cancerous (MCF-7 and NCI-H187) and nonmalignant (Vero) cells. Miaosporone A has antibacterial activity against Mycobacterium tuberculos... | |||
T39927 | Zeteletinib hemiadipate | BOS-172738 hemiadipate,DS-5010hemiadipate,Zeteletinib hemiadipate | |
Zeteletinib hemiadipate (BOS-172738; DS-5010) is an orally active compound that functions as a selective inhibitor of RET kinase. It exhibits nanomolar potency against RET and a 300-fold selectivity towards VEGFR2. Notab... | |||
T39320 | Hemiasterlin derivative-1 | ||
Hemiasterlin Derivative-1, a derivative of hemiasterlin, is utilized in the synthesis of Antibody-Drug Conjugates (ADC). | |||
T79921 | Moloney murine leukemia virus RT | DNA/RNA Synthesis | |
Moloney murine leukemia virus reverse transcriptase (MMLV RT) is a monomeric replicative polymerase intrinsic to the retrovirus life cycle [1]. | |||
T72097 | Eleven-Nineteen-Leukemia Protein IN-2 | Epigenetic Reader Domain | |
Eleven-Nineteen-Leukemia Protein IN-2 (compound 23), an ENL inhibitor, exhibits an IC50 of 10.7 nM and is utilized for leukemia research [1]. | |||
T60028 | MM41 | DNA/RNA Synthesis | |
MM41 is a human telomeric and gene promoter DNA quadruplex stabilizer with an IC50 of <10 nM against the MIA PaCa-2 pancreatic cancer cell line. | |||
T72576 | Transketolase-IN-4 | Antibacterial | |
Transketolase-IN-4 is a transketolase inhibitor with an IC50 value of 3.9 μM.Transketolase-IN-4 inhibited Mycobacterium tuberculosis DXS with an IC50 value of 114.1 μM. Transketolase-IN-4 inhibited the SW620, LS174T, and... | |||
T63136 | DX3-213B | OXPHOS | |
DX3-213B is a potent, orally active inhibitor of oxidative phosphorylation (OXPHOS) complex I with an IC50 of 3.6 nM. DX3-213B blocks ATP production (IC50: 11 nM) and inhibits the growth of MIA PaCa-2 cells (GI50: 11 nM)... | |||
T64093 | KRAS G12C inhibitor 44 | ||
KRAS G12C inhibitor 44 is a potent, orally active KRAS G12C inhibitor. KRAS G12C inhibitor 44 exhibits anti-proliferative effects in MIA PaCA-2 (IC50: 0.016 μM), H358 cells (IC50: 0.028 μM). inhibitor 44 has anti-tumour ... | |||
T79287 | SB-1295 | Reactive Oxygen Species | |
SB-1295, an orally active CDK9/T1 inhibitor with an IC50 of 0.17 μM, exhibits antiproliferative effects on HCT 116 and MIA PaCa-2 cells. It promotes cell death in MIA PaCa-2 by elevating intracellular ROS levels, diminis... | |||
T36514 | QD-394 | ||
QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to... | |||
T81850 | MASTL-IN-2 | ||
MASTL-IN-2 is a potent inhibitor of microtubule-associated serine/threonine kinase-like (MASTL). It demonstrates notable efficacy in suppressing the proliferation of human epithelial MIA PaCa cancer cells, exhibiting an ... | |||
T62737 | KRAS inhibitor-15 | ||
KRAS inhibitor-15 (compound 3-19) is a potent inhibitor of KRAS G12C (IC50: 0.954 μM). KRAS inhibitor-15 exhibits p-ERK inhibition in MIA PaCA-2, A549 cells with IC50s of 2.03, >33.3 μM, respectively. KRAS inhibitor-15 h... | |||
T62890 | OXPHOS-IN-1 | ||
OXPHOS-IN-1 (compound 2) is an inhibitor of oxidative phosphorylation (OXPHOS) and inhibits the growth of MIA PaCa-2 cells (IC50: 2.34 μM) and BxPC-3 cells (IC50: 13.82 μM). | |||
T63164 | KRAS inhibitor-13 | ||
KRAS inhibitor-13 (compound 5-6) is a potent inhibitor of KRAS G12C (IC50: 0.883 μM). KRAS inhibitor-13 has a p-ERK inhibitory effect in MIA PaCA-2, A549 cells with IC50 values of 5.9 and >100 μM respectively. KRAS inhib... | |||
T62751 | KRAS inhibitor-12 | ||
KRAS inhibitor-12 (compound 6-1) is a potent inhibitor of KRAS G12C (IC50: 0.537 μM). KRAS inhibitor-12 exhibits p-ERK inhibition in MIA PaCA-2, A549 cells with IC50 values of 1.3, 3.7 μM respectively. KRAS inhibitor-12 ... | |||
T63863 | KRAS G12C inhibitor 47 | ||
KRAS G12C inhibitor 47 is a potent inhibitor of KRAS G12C (IC50: 0.172 μM). KRAS G12C inhibitor 47 exhibits p-ERK inhibition in MIA PaCA-2 cells, A549 cells with IC50 values of 0.046 μM and 69.8 μM respectively. KRAS G12... | |||
T79808 | KRAS G12C inhibitor 61 | ERK | |
KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM. This inhibitor is applicable in the research of pancreatic, colorecta... | |||
T62752 | KRAS inhibitor-16 | ||
KRAS inhibitor-16 (compound 3-11) is a potent inhibitor of KRAS G12C (IC50: 0.457 μM). KRAS inhibitor-16 exhibits p-ERK inhibition in MIA PaCA-2, A549 cells with IC50s of 3.06, 11.1 μM respectively. KRAS inhibitor-16 has... | |||
T78896 | SHP2-IN-22 | ||
SHP2-IN-22, a potent SHP2 allosteric inhibitor, exhibits an IC50 value of 17.7 nM and effectively suppresses proliferation, migration, and invasion in MIA PaCa-2 pancreatic cancer cells. This compound is utilized in the ... | |||
T64150 | CX-5461 dihydrochloride | ||
CX-5461 dihydrochloride is a potent, orally active inhibitor of Pol I-mediated rRNA synthesis that acts on HCT-116 cells (IC50: 142 nM), A375 cells (IC50: 113 nM) and MIA PaCa-2 cells (IC50: 54 nM), and to a lesser exten... | |||
T63235 | KRAS inhibitor-14 | ||
KRAS inhibitor-14 is a potent inhibitor of KRAS G12C (IC50: 0.249 μM). KRAS inhibitor-14 exhibited p-ERK inhibition in MIA PaCA-2, A549 cells with IC50s of 1.12, >33.3 μM, respectively. KRAS inhibitor-14 has potential to... | |||
T62784 | KRAS inhibitor-18 | ||
KRAS inhibitor-18 (compound 3-10) is a potent inhibitor of KRAS G12C (IC50: 4.74 μM). KRAS inhibitor-18 exhibited p-ERK inhibition in MIA PaCA-2, A549 cells with IC50s of 66.4, 11.1 μM respectively. KRAS inhibitor-18 has... | |||
T78844 | MET/PDGFRA-IN-2 | c-Met/HGFR | |
MET/PDGFRA-IN-2 (compound 8h) serves as an inhibitor of MET and PDGFRA proteins, promoting apoptosis in cells and impeding the proliferation of MET-positive cells with IC50 values of 9.7, 6.1, 12.0, 11.5, 8.6, and 34.4 μ... | |||
T62981 | KRAS inhibitor-17 | ||
KRAS inhibitor-17 (compound 3-9) is a potent inhibitor of KRAS G12C (IC50: 3.37 μM). KRAS inhibitor-17 exhibits p-ERK inhibition with IC50 = 9.25 μM in MIA PaCA-2 cells and >33.3 μM in A549 cells. KRAS inhibitor-17 has t... | |||
T73255 | Akt1-IN-1 | ||
Akt1-IN-1 is a potent and selective inhibitor of Akt1, demonstrating an IC50 of 18.79 nM in MIA PaCa-2 cells, indicating its high efficacy in inhibiting this specific kinase. Notably, it shows no significant teratogenici... | |||
T80750 | YN14 | PROTACs | |
YN14 is a highly potent and selective KRASG12C proteolysis targeting chimera (PROTAC) capable of forming a stable KRASG12C: YN14: VHL ternary complex with low binding free energy (ΔG). It exhibits antiproliferative effec... | |||
T78843 | MET/PDGFRA-IN-1 | c-Met/HGFR | |
MET/PDGFRA-IN-1 (compound 8c) serves as an inhibitor of MET and PDGFRA proteins, displaying an IC50 of 36 μM against MET. It impedes MET phosphorylation, thereby promoting apoptosis, and curtails the proliferation of var... | |||
T36103 | TW9 | TW9 | |
TW9 is a dual inhibitor of bromodomain 2 (BD2) in bromodomain-containing protein 4 (BRD4) and histone deacetylase 1 (HDAC1; IC50s = 0.074 and 0.29 μM, respectively).1It is selective for BD2 over BD1 in BRD4 (IC50= 0.72 μ... | |||
T6069 | Gemcitabine hydrochloride | Gemcitabine HCl,Gemzar,LY188011,LY 188011 hydrochloride | Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , Autophagy |
Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy a... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2S2109 | Skimmianine | beta-Fagarine,Skimmianin,Chloroxylonine,Skimmiamine | Others |
1. Skimmianine (Chloroxylonine) is a spasmolytic agent. 2. Skimmianine (Chloroxylonine) shows pharmacol. props. similar to 2-(Methylamino)-1-phenyl-1-propanol BCJ45-G. | |||
T0783 | Mianserin hydrochloride | Mianserin HCl,Org GB 94,ORG GB-94 HCl | Dopamine Receptor , 5-HT Receptor , Opioid Receptor , Adrenergic Receptor , Histamine Receptor |
Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may cause drowsiness and hematolog... | |||
T19876 | Simiarenol | UNII-6OU4M247SJ,Simiaren-3beta-ol,beta-Simiarenol | |
Simiarenol may have leishmanicidal activity against Leishmania donovani promastigotes in vitro. | |||
TN4827 | Preskimmianine | Others | |
Preskimmianine is the biogenetic precursor of skimmianine.It can significantly inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated BV2 cells. | |||
TN5362 | 20-Dehydroeupatoriopicrin semiacetal | ||
20-Dehydroeupatoriopicrin semiacetal is a natural product for research related to life sciences. The catalog number is TN5362 and the CAS number is 94234-24-9. | |||
TN5025 | Simiarenone | Others | |
Simiarenone is a natural product of Euphorbia, Euphorbiaceae. The catalog number is TN5025 and the CAS number is 2318-78-7. Simiarenone can be used as a reference standard. | |||
TN4987 | Semialactone | Others | |
Semialactone shows inhibitory activities on human acyl-CoA:cholesterol acyltransferase(hACAT)1 with IC50 values of 79.1 uM and on human hACAT2 with IC50 values of 76.9 uM, it may be effective in the prevention and treatm... | |||
TN3282 | 8-Hydroxyhyperforin 8,1-hemiacetal | Others | |
8-Hydroxyhyperforin 8,1-hemiacetal is a natural product for research related to life sciences. The catalog number is TN3282 and the CAS number is 59014-02-7. | |||
T32055 | Hemiasterlin | NSC 695242,NSC-695242,Milnamide B,NSC695242,(-)-Hemiasterlin | |
Hemiasterlin is a cytotoxic peptide that acts by inducing mitotic arrest and abnormal spindle formation. | |||
TN5024 | Simiarenol acetate | Others | |
Simiarenol acetate is a natural product for research related to life sciences. The catalog number is TN5024 and the CAS number is 4965-99-5. | |||
TN5789 | Royleanone | ||
Royleanone possesses cytotoxic activity against the human pancreatic cancer cell line MIA PaCa-2. | |||
T36797 | 1-Alaninechlamydocin | ||
1-Alaninechalmydocin is a fungal metabolite originally isolated from a Great Lakes-derived Tolypocladium sp. and an inhibitor of histone deacetylases (HDACs). It reduces total HDAC activity in HeLa cell lysates in a conc... | |||
T36954 | Nemorosone | ||
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma ce... | |||
T36489 | Malformin A | ||
Malformin A is a cyclopentapeptide fungal metabolite that has been found in A. niger and has diverse biological activities. It is a plant growth regulator that induces malformations in plant structure. Malformin A inhib... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01137 | MIA Protein, Human, Recombinant (His) | Human | E. coli |
Melanoma Inhibitory Activity Protein (MIA) is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells, which was the first discovered member of a family of secreted cytokines termed... | |||
TMPH-00365 | Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His) | CAV | E. coli |
May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His) is expressed in E. coli expression system ... | |||
TMPH-02465 | Moloney murine leukemia virus (MoMLV) (isolate Shinnick) Gag polyprotein (GST) | MoMLV | E. coli |
Moloney murine leukemia virus (MoMLV) (isolate Shinnick) Gag polyprotein (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 57.6 kDa and the accession number is P03332. | |||
TMPY-00328 | Simian immunodeficiency virus (SIV) (isolate F236) gp120 Protein (His) | SIV | HEK293 Cells |
Simian immunodeficiency virus (SIV) (isolate F236) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.8 kDa and the accession number is P12492. | |||
TMPH-03509 | Simian immunodeficiency virus (SIV) (isolate PBj14/BCL-3) Vpx Protein (His & SUMO) | SIV | E. coli |
Simian immunodeficiency virus (SIV) (isolate PBj14/BCL-3) Vpx Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 28.9 kDa and the accession number is P... | |||
TMPY-05144 | Blo t 5 Protein, Blomia tropicalis, Recombinant (His) | Blomia tropicalis | P. pastoris (Yeast) |
Blo t 5 Protein, Blomia tropicalis, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 15.3 kDa and the accession number is O96870.1. | |||
TMPH-03511 | Simian virus 40 (SV40) SV40 early leader Protein (His & KSI) | SV40 | E. coli |
May play a role in the lytic cycle. Simian virus 40 (SV40) SV40 early leader Protein (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 18.0 kDa and the accessio... | |||
TMPH-03510 | Simian virus 40 (SV40) SV40 early leader Protein (hFc) | SV40 | HEK293 Cells |
May play a role in the lytic cycle. Simian virus 40 (SV40) SV40 early leader Protein (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 31.6 kDa and the accession number is P0C... | |||
TMPH-00367 | Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO) | CAV | E. coli |
May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO) is expressed in E. coli e... | |||
TMPY-05143 | Blo t 2 Protein, Blomia tropicalis, Recombinant (His) | Blomia tropicalis | HEK293 Cells |
Blo t 2 Protein, Blomia tropicalis, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is Q1M2P1. | |||
TMPY-00336 | Simian immunodeficiency virus (SIV) (isolate 216.94.A2) gp120 Protein (His) | SIV | HEK293 Cells |
Simian immunodeficiency virus (SIV) (isolate 216.94.A2) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is E2EXP2. | |||
TMPH-00366 | Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST) | CAV | E. coli |
May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST) is expressed in E. coli expressi... | |||
TMPY-05145 | Blo t 21 Protein, Blomia tropicalis, Recombinant (His) | Blomia tropicalis | E. coli |
Blo t 21 Protein, Blomia tropicalis, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.2 kDa and the accession number is A7IZE9. | |||
TMPY-00331 | Simian immunodeficiency virus (SIV) (isolate SIVmac251v31523ru28) gp120 Protein (His) | SIV | HEK293 Cells |
Simian immunodeficiency virus (SIV) (isolate SIVmac251v31523ru28) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.6 kDa and the accession number is D7PU90. | |||
TMPY-05142 | Blo t 1 Protein, Blomia tropicalis, Recombinant (His) | Blomia tropicalis | P. pastoris (Yeast) |
Blo t 1 Protein, Blomia tropicalis, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 37.7 kDa and the accession number is A1KXI0. |
Cat No. | Product Name | ||
---|---|---|---|
L6230 | Miao medicine Compound Library | 534 compounds | |
A unique collection of 534 compounds featuring natural product molecules derived from Miao medicine that can be used for high-throughput and high-content screening. |