Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may cause drowsiness and hematological problems.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 32.00 | |
50 mg | In stock | $ 46.00 | |
100 mg | In stock | $ 58.00 | |
200 mg | In stock | $ 98.00 | |
500 mg | In stock | $ 180.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 39.00 |
Description | Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may cause drowsiness and hematological problems. |
In vitro | Mianserin dose-dependently elevates extracellular norepinephrine levels in the prefrontal cortex with minimal impact on the reuptake of norepinephrine in the rat cerebral cortex, due to its blockade of presynaptic inhibitory α2-adrenergic receptors and induction of regeneration-mediated release enhancement. In neonatal 6-OHDA-lesioned rats, mianserin attenuates the effects of SKF38393 and M-CPP, indicating that the actions of dopamine receptor agonists are mediated through the 5-HT neurochemical system. Additionally, in the medial prefrontal cortex of neonatal 6-OHDA-lesioned rats, 10 mg/kg S.C. Mianserin increased extracellular dopamine approximately 6-fold. |
In vivo | In elevated plus-maze experiments, Eltoprazine and Mianserin exhibit opposite effects: Eltoprazine induces anxiogenic-like behavior, while Mianserin triggers an anxiolytic-like response. Mianserin leads to a decreased number of these sites, whereas Eltoprazine results in an increase. Additionally, a subcutaneous dose of 2 mg/kg Mianserin produces a significant statistical increase in dopamine levels, exceeding 30% when compared to saline. |
Synonyms | Mianserin HCl, Org GB 94, ORG GB-94 HCl |
Molecular Weight | 300.83 |
Formula | C18H21ClN2 |
CAS No. | 21535-47-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 99.7 mM
DMSO: 199.4 mM
You can also refer to dose conversion for different animals. More
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Mianserin hydrochloride 21535-47-7 Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation Neuroscience Opioid Receptor 5-HT Receptor Adrenergic Receptor Histamine Receptor Dopamine Receptor Mianserin HCl Org GB94 Inhibitor inhibit Mianserin Hydrochloride Org GB 94 Org GB-94 Mianserin ORG GB-94 HCl inhibitor