jurkat — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9503	PHYTOSPHINGOSINE		Apoptosis
	Phytosphingosine is a phospholipid with anticancer properties. In cancer cells, Phytosphingosine induces cell apoptosis through activation of caspase 8 and translocation of Bax.		Apoptosis
T30751	Carotegrast methyl	AJM300	Integrin
	Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.		Integrin
T9104	TJ191		Apoptosis
	TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.		Apoptosis
T16133	MRK-560		Gamma-secretase
	MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase.		Gamma-secretase
T9595	LP-261		Microtubule Associated
	LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.		Microtubule Associated
T6603	Nelarabine	GW 506U78,Nelzarabine,506U78	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis
	Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
T9079	Apostatin-1	Apt-1	Others
	Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.		Others
T3977	Lifitegrast	SHP-606,SAR 1118	Integrin
	Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.		Integrin
T9218	Andrograpanin	19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE	p38 MAPK
	Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) is a bioactive compound from Andrographis paniculata. Andrograpanin has anti-inflammatory and anti-infectious properties.		p38 MAPK
T0370	Pheniramine maleate	Daneral,Inhiston,Trimetose	5-HT Receptor , Histamine Receptor
	Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re...		5-HT Receptor , Histamine Receptor
T5858	Sertindole	Lu 23-174	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
	Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T3884	Neoandrographolide	Neoandrographiside	NOS , COX
	Neoandrographolide (Neoandrographiside) has potent hypolipidemic effect and protects the cardiovascular without significant liver damage.Neoandrographolide has anti-inflammatory effect, might result from inhibition of iN...		NOS , COX
T64387	2-Nitrobenzoic acid	o-Nitrobenzoic acid	Others
	2-Nitrobenzoic acid (o-Nitrobenzoic acid) is a antiproliferation agent. 2-Nitrobenzoic acid shows IC50 of 8.3 μM to jurkat cell line expressing T type calcium channel alpha 1H or its splice variant delta 25.		Others
T37558	Necrostatin-5	Nec-5	RIP kinase , Necroptosis
	Necrostatin-5 (Nec-5) is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α with an EC50 value of 240 nM.		RIP kinase , Necroptosis
T35569	CTA 056		Apoptosis
	CTA 056 is an interleukin-2 induced T cell kinase (ITK) inhibitor, inhibits the growth of MOLT-4 xenograft tumors in mice, induces apoptosis in Jurkat cells, and can be used in the study of autoimmune disorders and T cel...		Apoptosis
T24816	SP-100030	SP100030,SP 100030	NF-κB
	SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and ...		NF-κB
TL0013	Heraclenin		Anti-infection , Immunology/Inflammation related
	Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Her...		Anti-infection , Immunology/Inflammation related
T10565	BMS-1001 hydrochloride		PD-1/PD-L1
	BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activat...		PD-1/PD-L1
T5320	Tulipalin A	α-methylene-γ-butyrolactone,2-Methylenebutyrolactone	Others , Drug Metabolite
	Tulipalin A (α-methylene-γ-butyrolactone) (2-Methylenebutyrolactone) which has some phytotoxicity is a natural compound extracted from Tulipa gesneriana.		Others , Drug Metabolite
T16075	(Rac)-Idroxioleic acid	2-Hydroxyoleic acid,2-OHOA,Minerval	Apoptosis
	(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a fatty acid amide hydrolase inhibitor with anti-tumor effect. It binds to the plasma membrane and alters lipid organization.		Apoptosis