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Pheniramine maleate

Catalog No. T0370 CAS 132-20-7

Synonyms: Daneral, Inhiston, Trimetose

Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived relaxing factor, nitric oxide.

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Pheniramine maleate, CAS 132-20-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 30.00
50 mg	In stock	$ 38.00
100 mg	In stock	$ 50.00
200 mg	In stock	$ 60.00
500 mg	In stock	$ 93.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

Pheniramine maleate binds to histamine H1 receptors, which inhibits the production of phospholipase A2 and the endothelium-derived relaxing factor NO. This leads to a reduction in the activation of guanylate cyclase due to NO deficiency, resulting in decreased levels of cyclic GMP (cGMP). Consequently, this suppresses the contraction of smooth muscle tissues, reduces capillary permeability, and diminishes histamine-induced allergic responses.

Synonyms	Daneral, Inhiston, Trimetose
Molecular Weight	356.42
Formula	C16H20N2·C4H4O4
CAS No.	132-20-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 65 mg/mL (182.4 mM)

Ethanol: 66 mg/mL (185.2 mM)

DMSO: 66 mg/mL (185.2 mM)

References and Literature

1. Moharana AK, et al. Indian J Physiol Pharmacol. 2000, 44(2), 153-160.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library GPCR Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Neuronal Signaling Compound Library Anti-Obesity Compound Library

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Keywords

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