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Lifitegrast

Name: Lifitegrast
Brand: TargetMol
SKU: T3977
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3977Cas No. 1025967-78-5

Alias SHP-606, SAR 1118

Lifitegrast (SAR 1118) is an antagonist of lymphocyte function-associated antigen-1.

Lifitegrast

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Purity: 99.66%

Catalog No. T3977Alias SHP-606, SAR 1118Cas No. 1025967-78-5

Lifitegrast (SAR 1118) is an antagonist of lymphocyte function-associated antigen-1.

Pack Size	Price	Availability
5 mg	$33	In Stock
10 mg	$52	In Stock
25 mg	$93	In Stock
50 mg	$147	In Stock
100 mg	$239	In Stock
500 mg	$588	In Stock
1 mL x 10 mM (in DMSO)	$55	In Stock

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Purity:99.66%

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Product Introduction

Bioactivity

Description	Lifitegrast (SAR 1118) is an antagonist of lymphocyte function-associated antigen-1.
Targets&IC50	LFA1:2.98 nM.
In vitro	Lifitegrast is a novel small molecule integrin antagonist that inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses. Lifitegrast strongly inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM[1].
In vivo	Lifitegrast, has potent anti-inflammatory activity on corneal inflammation induced by antibiotic-killed P. aeruginosa and S. aureus in the presence of a silicone hydrogel lens with the optimal application being a 1% solution applied either 2 or 3 times prior. Topical application of lifitegrast to the corneal surface of healthy adults is safe and well tolerated[2]. SAR 1118 ophthalmic drops administered thrice daily deliver therapeutic levels of SAR 1118 in the retina and can alleviate the retinal complications associated with diabetes[3].
Synonyms	SHP-606, SAR 1118

Chemical Properties

Molecular Weight	615.48
Formula	C₂₉H₂₄Cl₂N₂O₇S
Cas No.	1025967-78-5
Smiles	CS(=O)(=O)c1cccc(C[C@H](NC(=O)c2c(Cl)cc3CN(CCc3c2Cl)C(=O)c2ccc3ccoc3c2)C(O)=O)c1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (81.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6247 mL	8.1237 mL	16.2475 mL	81.2374 mL
5 mM	0.3249 mL	1.6247 mL	3.2495 mL	16.2475 mL
10 mM	0.1625 mL	0.8124 mL	1.6247 mL	8.1237 mL
20 mM	0.0812 mL	0.4062 mL	0.8124 mL	4.0619 mL
50 mM	0.0325 mL	0.1625 mL	0.3249 mL	1.6247 mL

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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