Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 36.00 | |
10 mg | In stock | $ 52.00 | |
25 mg | In stock | $ 94.00 | |
50 mg | In stock | $ 163.00 | |
100 mg | In stock | $ 271.00 | |
500 mg | In stock | $ 663.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 55.00 |
Description | Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist. |
Targets&IC50 | LFA1:2.98 nM. |
In vitro | Lifitegrast is a novel small molecule integrin antagonist that inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses. Lifitegrast strongly inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM[1]. |
In vivo | Lifitegrast, has potent anti-inflammatory activity on corneal inflammation induced by antibiotic-killed P. aeruginosa and S. aureus in the presence of a silicone hydrogel lens with the optimal application being a 1% solution applied either 2 or 3 times prior. Topical application of lifitegrast to the corneal surface of healthy adults is safe and well tolerated[2]. SAR 1118 ophthalmic drops administered thrice daily deliver therapeutic levels of SAR 1118 in the retina and can alleviate the retinal complications associated with diabetes[3]. |
Synonyms | SHP-606, SAR 1118 |
Molecular Weight | 615.48 |
Formula | C29H24Cl2N2O7S |
CAS No. | 1025967-78-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 29 mg/mL
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Lifitegrast 1025967-78-5 Cytoskeletal Signaling Integrin ICAM-1 T cell SHP-606 inhibit SAR 1118 SHP606 SHP 606 dry eye disease SAR-1118 Jurkat T LFA-1 SAR1118 inflammatory cycle Inhibitor inhibitor