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Heraclenin

Catalog No. TL0013 CAS 2880-49-1

Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Heraclenin displays significant levels of antiplasmodial and moderate levels of antimicrobial activities.

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Heraclenin, CAS 2880-49-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
5 mg	In stock	$ 196.00
10 mg	In stock	$ 295.00
25 mg	In stock	$ 497.00
50 mg	In stock	$ 723.00
1 mL * 10 mM (in DMSO)	In stock	$ 210.00

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Purity: 98.95%

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Description	Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Heraclenin displays significant levels of antiplasmodial and moderate levels of antimicrobial activities.
In vitro	METHODS AND RESULTS:Heraclenin, a furocoumarin with an epoxide group in its side chain, was analyzed to see if it induced structural chromosome aberrations and sister-chromatid exchanges (SCEs) in human lymphocytes in vitro. The results were compared directly with those of imperatorin, which differs from Heraclenin only in lacking an epoxide group. An equally strong clastogenic effect was found for both Heraclenin and imperatorin: the number of metaphases with breaks was increased in both cases by approximately a factor of 6. Heraclenin produced a considerable dose-dependent increase in the SCE rate, i.e., by about 60 induced SCEs/metaphase, whereas imperatorin induced only about 4 SCEs/metaphase. CONCLUSIONS: The results are discussed with respect to the occurrence of structural aberrations, which are primarily due to the basic furocoumarin structure itself, whereas the large increase in the SCE rate produced by Heraclenin is most probably significantly influenced by its epoxide group.
Source	Natural Products > Rutaceae > Citrus

Molecular Weight	286.28
Formula	C16H14O5
CAS No.	2880-49-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (87.33 mM)

References and Literature

1. Chromosome-damaging effects of heraclenin in human lymphocytes in vitro. Mutat Res. 1986 Jan-Feb;169(1-2):51-4. 2. Mutagenicity of a furocoumarin epoxide, heraclenin, in Chlamydomonas reinhardii. Mutat Res. 1986 Jan-Feb;169(1-2):47-50. 3. Microbial transformation of (+)-heraclenin by Aspergillus niger and evaluation of its antiplasmodial and antimicrobial activities. Curr. Sci., 2011, 100(11):1706-11.

Related compound libraries

This product is contained In the following compound libraries：

NO PAINS Compound Library Covalent Natural Product Library Anti-Infection Compound Library Bioactive Compounds Library Max Natural Product Library Covalent Inhibitor Library Human Metabolite Library Selected Plant-Sourced Compound Library Bioactive Compound Library Hematonosis Compound Library

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Keywords

Heraclenin 2880-49-1 Immunology/Inflammation Microbiology/Virology Immunology/Inflammation related Anti-infection inhibit Inhibitor inhibitor

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