hcc — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T32039	HADA Hydrochloride	HCC-Amino-D-alanine hydrochloride,HADA HCl	Autophagy
	HADA Hydrochloride (HCC-Amino-D-alanine hydrochloride) is a blue (λem~450 nm) fluorescent D-amino acid (FDAA). FDAAs are efficiently incorporated into the peptidoglycans (PGs) of diverse bacterial species at the sites of...		Autophagy
T5484	GSK467		Histone Demethylase , Histone Methyltransferase
	GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).		Histone Demethylase , Histone Methyltransferase
T6133	Remodelin hydrobromide	Remodelin,Remodelin HBR	RAAS , Histone Acetyltransferase
	Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.		RAAS , Histone Acetyltransferase
T21635	PD184161		MEK
	PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].		MEK
T5414	Glumetinib	SCC244	c-Met/HGFR
	Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).		c-Met/HGFR
T6670	Silymarin	Silybin B	SARS-CoV
	Silymarin (Silybin B) (Silybin B) is a polyphenolic flavonoid that extracts from the milk thistle or seeds of Silybum marianum. It is used in the prevention and treatment of liver diseases.		SARS-CoV
T1575	Nizatidine	Axid,Acinon,Zanizal	AChE , Histamine Receptor
	Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.		AChE , Histamine Receptor
T7008	Vacquinol-1	Vacquinol 1	JNK
	Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.		JNK
T6797	Telaglenastat	CB 839,CB839,CB-839	transporter , Glutaminase , Autophagy
	Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.		transporter , Glutaminase , Autophagy
T1785	Palbociclib	PD 0332991	CDK
	Palbociclib (PD 0332991) is a CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11/16 nM) and is orally active. Palbociclib has anti-tumorigenic activity and has investigational potential for use in ER-positive and HER2-ne...		CDK
T1900	LDN-212854	LDN212854,BMP Inhibitor III	ALK , TGF-beta/Smad
	LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors.		ALK , TGF-beta/Smad
T6481	Droxinostat	NS 41080	Apoptosis , HDAC
	Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10.		Apoptosis , HDAC
T6S0117	Avicularin	Fenicularin	ERK
	Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX...		ERK
T0334	Rosiglitazone	BRL49653	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
T22443	Triglycidyl isocyanurate	Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,TGI	Apoptosis
	Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alk...		Apoptosis
T9945	MNK8	3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione	STAT
	MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1].		STAT
T6646	Rosiglitazone hydrochloride	BRL-49653 HCl,Rosiglitazone HCl	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
T6239	Palbociclib monohydrochloride	PD 0332991 hydrochloride,Palbociclib hydrochloride,Palbociclib (PD-0332991) HCl	CDK
	Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases.		CDK
T6240	Palbociclib Isethionate	Palbociclib (PD0332991) Isethionate,PD 0332991 isethionate	CDK
	Palbociclib Isethionate (PD 0332991 isethionate) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases.		CDK
T7060	Amantadine	1-Aminoadamantane,1-Adamantanamine,1-Adamantylamine	Others
	Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.		Others