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MNK8

Catalog No. T9945 CAS 2055078-49-2

Synonyms: 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione

MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MNK8 , CAS 2055078-49-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
2 mg	In stock	$ 59.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 155.00
25 mg	In stock	$ 289.00
50 mg	In stock	$ 396.00
100 mg	In stock	$ 593.00
500 mg	In stock	$ 1,250.00
1 mL * 10 mM (in DMSO)	In stock	$ 94.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1].
In vitro	MNK8, at a concentration of 50 μM over a period of 0 to 48 hours, resulted in a time-dependent increase in Sub-G1 cells and concurrently led to a reduction in the levels of antiapoptotic proteins, namely Bcl-2, survivin, and cyclin D1 [1].

Synonyms	3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione
Molecular Weight	252.27
Formula	C15H12N2O2
CAS No.	2055078-49-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (218.02 mM)

References and Literature

1. Ayyiliath M Sajith, et al. Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells. Bioorg Med Chem Lett. 2021 Oct 15;50:128332.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Inhibitor Library Anti-Cancer Metabolism Compound Library Anti-Pancreatic Cancer Compound Library Anti-Lung Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Prostate Cancer Compound Library Anti-Liver Cancer Compound Library Immunology/Inflammation Compound Library

Related Products

Related compounds with same targets

AS2863619 Homoharringtonine Tetramethylcurcumin Physalin A STAT3-IN-1 Kurarinone TLC1566-0618 Isolinderalactone

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MNK8 2055078-49-2 JAK/STAT signaling Stem Cells STAT MNK 8 HepG2 Bcl-2 Family STAT3 inhibitor inhibit Antimigratory agent Inhibitor N-methyluracil derivatives hepatocellular carcinoma Survivin Anticancer 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione HCC cells Apoptosis MNK8 MNK-8 inhibitor

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