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Nizatidine

Catalog No. T1575 CAS 76963-41-2

Synonyms: Axid, Acinon, Zanizal

Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.

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Nizatidine, CAS 76963-41-2

Pack Size	Availability	Price/USD
100 mg	In stock	$ 41.00
1 g	In stock	$ 54.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.87%

Purity: 99.43%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.
Targets&IC50	H2 receptor:0.9 nM, AChE:6.7 μM
In vitro	In rats, Nizatidine exhibits its maximum inhibitory effect on gastric acid secretion one hour after administration, with an EC50 value of 1.383 μMol/kg. Intravenous administration of Nizatidine (0.3-3 mg/kg) not only enhances gastrointestinal motility but also suppresses gastric acid secretion, achieving 50% of the maximal effect at a dose of 2.94 mg/kg and 90% at 19.6 mg/kg for rats.
In vivo	Nizatidine is a reversible, non-competitive inhibitor of acetylcholinesterase (IC50=6.7 μM, Ki=7.4 μM) and a selective antagonist of the histamine H2 receptor, effectively inhibiting gastric acid secretion (IC50=0.9 nM).

Synonyms	Axid, Acinon, Zanizal
Molecular Weight	331.46
Formula	C12H21N5O2S2
CAS No.	76963-41-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 61 mg/mL (184 mM)

H2O: 26 mg/mL (78.4 mM)

Ethanol: 15 mg/mL (45.3 mM)

References and Literature

1. Lin TM, et al. J Pharmacol Exp Ther, 1986, 239(2), 406-410. 2. Ueki S, et al. J Pharmacol Exp Ther, 1993, 264(1), 152-157.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Cancer Clinical Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library GPCR Compound Library Anti-Neurodegenerative Disease Compound Library NO PAINS Compound Library FDA-Approved & Pharmacopeia Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nizatidine 76963-41-2 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor AChE cancer gastroesophageal reflux disease inhibit intestines ulcers Axid hcc stomach Acinon Inhibitor erosive esophagitis Zanizal acid GERD inhibitor

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