gsk-a-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T27499	GSK-A1		HCV Protease , PI4K
	GSK-A1 is a specific inhibitor of PI4KA, also inhibited calcium-driven PRL secretion without affecting calcium signaling and Prl expression. GSK-A1 has anti-hepatitis C virus (HCV) potential.		HCV Protease , PI4K
T1906	Molibresib	GSK 525762A,GSK525762,I-BET 762	Epigenetic Reader Domain
	Molibresib (GSK525762) is an inhibitor of BET proteins (IC50: about 35 nM).		Epigenetic Reader Domain
T7361	Verucerfont	NBI77860,GSK561679	CRFR
	Verucerfont (NBI77860) is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .		CRFR
T64366	GSK3-IN-4		GSK-3
	GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.		GSK-3
T9178	(E/Z)-GSK-3β inhibitor 1	GSK-3β inhibitor 1	GSK-3
	(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.		GSK-3
T6129	GSK-1070916	GSK-1070916A,GSK1070916	Apoptosis , Tie-2 , FLT , AMPK , Aurora Kinase
	GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1.		Apoptosis , Tie-2 , FLT , AMPK , Aurora Kinase
T14613	BIP-135		GSK-3
	BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1].		GSK-3
T61809	GSK-3β inhibitor 11		GSK-3
	GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM. This compound demonstrates potential utility in the field of neurodegen...		GSK-3
T2622	GSK 650394	GSK650394	SGK , Influenza Virus
	GSK 650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor.		SGK , Influenza Virus
T6358	1-Azakenpaullone	azakenpaullone	GSK-3
	1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.		GSK-3
T6003	GSK1904529A	GSK 4529	Apoptosis , Raf , VEGFR , IGF-1R , Syk
	GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .		Apoptosis , Raf , VEGFR , IGF-1R , Syk
T61360	ARN25068		GSK-3 , DYRK , Microtubule Associated , Src
	ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation [1].		GSK-3 , DYRK , Microtubule Associated , Src
T16850	SB-265610	GSK-CXCR2	CXCR
	SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis (IC50s: 3.7 nM and...		CXCR
T2310L	CHIR-99021 HCl	CT99021 HCl,Laduviglusib HCl	GSK-3
	CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3α/β, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivit...		GSK-3
T6285	GSK-690693	GSK690693	Serine Protease , Akt , PKC , AMPK , Autophagy
	GSK-690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. Phase 1.		Serine Protease , Akt , PKC , AMPK , Autophagy
T22341	GSK-114		Others
	GSK-114, a selective inhibitor of TNNI3 Interacting Kinase (TNNI3K) with IC50 of 25 nM, shows significant bias for TNNI3K over B-Raf with IC50 of 1000 nM, exceptional broad spectrum kinase selectivity and adequate oral e...		Others
T60485	DIF-3
	DIF-3 is a chemical compound that acts by activating GSK-3β to facilitate the degradation of cyclin D1 and c-Myc, resulting in reduced expression levels of these proteins. In addition, DIF-3 inhibits Wnt/β-catenin signal...
T6458	CYC-116		VEGFR , FLT , CDK , S6 Kinase , Aurora Kinase
	CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 ...		VEGFR , FLT , CDK , S6 Kinase , Aurora Kinase
TN5171	Tricetin		Apoptosis , Others , Nrf2
	Tricetin is a flavonoid isolated from pomegranate.Tricetin is a potent competitive inhibitor of Keap1-Nrf2 protein-protein interaction (PPI) and protects Parkinson's disease patients from 6-OHDA-induced neurotoxicity by ...		Apoptosis , Others , Nrf2
T6S0653	Linarin	Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine	TNF , AChE
	1. Linarin (Acacetin-7-O-rutinoside) (acacetin-7-O-β-d-rutinoside) shows selective dose dependent inhibitory effect on acetylcholinesterase. 2. Linarin alleviates GalN/LPS-induced liver injury by suppressing TNF-α-mediat...		TNF , AChE