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GSK-A1

Catalog No. T27499 CAS 1416334-69-4

GSK-A1 is a specific inhibitor of PI4KA, also inhibited calcium-driven PRL secretion without affecting calcium signaling and Prl expression. GSK-A1 has anti-hepatitis C virus (HCV) potential.

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GSK-A1, CAS 1416334-69-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSK-A1 is a specific inhibitor of PI4KA, also inhibited calcium-driven PRL secretion without affecting calcium signaling and Prl expression. GSK-A1 has anti-hepatitis C virus (HCV) potential.
Targets&IC50	PI4K2B:<5 (pIC50), PI4KB:7.2-7.7 (pIC50), PI4K2A:<5 (pIC50), PI4KA:8.5-9.8 (pIC50)
In vitro	GSK-A1 is a selective?type III phosphatidylinositol 4-kinase PI4KA (PI4KIIIα)?inhibitor with a?pIC50?of 8.5-9.8[3]. GSK-A1 potently decreases the levels of PtdIns(4)P with a negligible effect on PtdIns(4,5)P2[3].

Molecular Weight	574.63
Formula	C29H27FN6O4S
CAS No.	1416334-69-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Beebe SJ, Reimann EM, Schlender KK. Purification and characterization of a cAMP- and Ca2+-calmodulin-independent glycogen synthase kinase from porcine renal cortex. J Biol Chem. 1984 Feb 10;259(3):1415-22. PubMed PMID: 6319398.

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Keywords

GSK-A1 1416334-69-4 PI3K/Akt/mTOR信号通路蛋白酶体微生物学 HCV Protease PI4K PtdIns(4,5)P2 PI4KIIIα inhibit Hepatitis C virus GSK A1 Phosphatidylinositol 4 kinases PtdIns(4)P phosphatidylinositol 4-kinase PI4KA HCV Inhibitor PI4 kinases GSKA1 GSK-A-1 inhibitor

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