cyp3a4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T64037	CYP3A4-IN-2
	CYP3A4-IN-2 is a specific inhibitor of cytochrome P450 3A4 (CYP3A4) (IC50: 0.055 μM). CYP3A4-IN-2 is a ritonavir analogue with a more hydrophobic R2 side group and stronger inhibition than ritonavir. CYP3A4-IN-2 is capab...
T64032	CYP3A4-IN-3
	CYP3A4-IN-3 is a specific, highly affinity cytochrome P450 3A4 (CYP3A4) (cytochrome P450 3A4 (CYP3A4)) inhibitor (IC50: 0.075 μM). CYP3A4-IN-3 is an analogue of ritonavir with a simpler structure and twice as much inhibi...
T63954	CYP3A4-IN-1
	CYP3A4-IN-1 is a potent inhibitor of cytochrome P450 3A4 (CYP3A4) (IC50: 0.085 μM).
T20626	Esomeprazole		Proton pump , Cysteine Protease
	Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).		Proton pump , Cysteine Protease
T10835	Cletoquine	Desethylhydroxychloroquine	Parasite , Antifection
	Cletoquine is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disease treatme...		Parasite , Antifection
T10423	AWZ1066S		Parasite
	AWZ1066S is a highly specific anti-Wolbachia drug candidate for the short-course treatment of filariasis (EC50: 2.5 nM in cell assay).		Parasite
T28827	Sofpironium bromide	BBI4000,BBI 4000,BBI-4000	Others , AChR
	Sofpironium bromide (BBI4000) belongs to a class of drugs called anticholinergics, which exert their effect by blocking the action of acetylcholine.		Others , AChR
T4697	ABBV-744	ABBV744	Epigenetic Reader Domain , HIV Protease
	ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.		Epigenetic Reader Domain , HIV Protease
T9054	RO6889678		HBV
	RO6889678 is HBV inhibitor with a complex ADME profile.		HBV
T2397	Topiroxostat	FYX-051	P450 , ROS , Xanthine Oxidase
	Topiroxostat (FYX-051) is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.		P450 , ROS , Xanthine Oxidase
T1434	Clarithromycin	A-56268	P450 , ribosome , MRP , Antibacterial , Antibiotic , Autophagy
	Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classif...
T2686L	Esomeprazole Sodium	(S)-Omeprazole sodium	ATPase , Proton pump
	Esomeprazole Sodium ((S)-Omeprazole sodium) is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the i...		ATPase , Proton pump
T6150	TAK-715		p38 MAPK , Casein Kinase , JNK
	TAK-715 is a p38 MAPK inhibitor for p38α.		p38 MAPK , Casein Kinase , JNK
T21404	Fluticasone furoate	Veramyst,Allermist,Avamys,Fluticasone furoate	Glucocorticoid Receptor
	Fluticasone furoate (Avamys) is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflammatory, anti-asthmatic activity, and low systemic exposure...		Glucocorticoid Receptor
T10989	Dehydroaripiprazole	OPC-14857,DM-14857	5-HT Receptor
	Dehydroaripiprazole (DM-14857) is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms dehydroaripiprazole. Dehydroaripiprazole has anti...		5-HT Receptor
T1290	Oxiconazole nitrate	Ro 13-8996	Others , Antibiotic , Antifection , Antifungal
	Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole...		Others , Antibiotic , Antifection , Antifungal
T12146	N-Desmethyl-Apalutamide	N-Desmethyl Apalutamide	P450 , Androgen Receptor
	N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.		P450 , Androgen Receptor
T20656	Verapamil	NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil	P450 , Calcium Channel , P-gp
	Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias...		P450 , Calcium Channel , P-gp
T1010	Verapamil hydrochloride	Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride	P450 , Calcium Channel , P-gp
	Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.		P450 , Calcium Channel , P-gp
T77698	HCYP3A4 Fluorogenic substrate 1		Others
	hCYP3A4 Fluorogenic substrate 1 is a phthalimide derivative and shows low activity against COX.		Others