Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fluticasone furoate (Avamys) is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflammatory, anti-asthmatic activity, and low systemic exposure. Fluticasone furoate can be used as a nasal spray for studies about allergic rhinitis treatment.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 30.00 | |
10 mg | In stock | $ 48.00 | |
25 mg | In stock | $ 84.00 | |
50 mg | In stock | $ 139.00 | |
100 mg | In stock | $ 197.00 | |
200 mg | In stock | $ 293.00 | |
500 mg | In stock | $ 497.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 53.00 |
Description | Fluticasone furoate (Avamys) is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflammatory, anti-asthmatic activity, and low systemic exposure. Fluticasone furoate can be used as a nasal spray for studies about allergic rhinitis treatment. |
Targets&IC50 | Corticosteroid:0.3 nM (Kd) |
In vitro | Fluticasone furoate displays great potency in inhibiting tumor necrosis factor synthesis and action. Fluticasone furoate prevents damage to cultured human lung epithelial cells by different stimuli[2]. |
In vivo | Fluticasone furonate is excreted mainly in the feces, with only minor amounts in the urine. Fluticasone furonate is 99.4% bound to plasma protein in vitro. Clearance of Fluticasone furonate is primarily by hydrolysis in the liver by the cytochrome P450 isozyme CYP3A4 that converts the drug to the 17β-carboxylic acid metabolite, which displays low glucocorticoid receptor agonist potency[2]. |
Synonyms | Veramyst, Allermist, Avamys, Fluticasone furoate |
Molecular Weight | 538.58 |
Formula | C27H29F3O6S |
CAS No. | 397864-44-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 95 mg/mL (176.39 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Fluticasone furoate 397864-44-7 Endocrinology/Hormones Glucocorticoid Receptor Inhibitor Veramyst fluorinated lipophilic rhinitis Allermist CYP3A4 Avamys inhibit intranasal allergic corticosteroid Fluticasone Furoate anti-asthmatic Anti-inflamatory inhibitor