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ABBV-744

Name: ABBV-744
Brand: TargetMol
SKU: T4697
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4697Cas No. 2138861-99-9

Alias ABBV744

ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.

ABBV-744

🥰Excellent

Purity: 99.79%

Catalog No. T4697Alias ABBV744Cas No. 2138861-99-9

ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.

Pack Size	Price	Availability
1 mg	$39	In Stock
2 mg	$54	In Stock
5 mg	$97	In Stock
10 mg	$153	In Stock
25 mg	$315	In Stock
50 mg	$455	In Stock
100 mg	$555	In Stock
200 mg	$798	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.79%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.
Targets&IC50	BRDT BD2:18 nM (IC50), BRD4 BD2:3 nM (Kd), BRD3 BD2:13 nM (IC50), BRD4 BD2:4 nM (IC50), BRD2 BD2:8 nM (IC50)
Synonyms	ABBV744

Chemical Properties

Molecular Weight	491.55
Formula	C₂₈H₃₀FN₃O₄
Cas No.	2138861-99-9
Smiles	CCNC(=O)c1cc2c(cn(C)c(=O)c2[nH]1)-c1cc(ccc1Oc1c(C)cc(F)cc1C)C(C)(C)O
Relative Density.	1.262 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (91.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0344 mL	10.1719 mL	20.3438 mL	101.7191 mL
5 mM	0.4069 mL	2.0344 mL	4.0688 mL	20.3438 mL
10 mM	0.2034 mL	1.0172 mL	2.0344 mL	10.1719 mL
20 mM	0.1017 mL	0.5086 mL	1.0172 mL	5.0860 mL
50 mM	0.0407 mL	0.2034 mL	0.4069 mL	2.0344 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc