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Immunology/Inflammation MRP Clarithromycin

Clarithromycin

Catalog No. T1434   CAS 81103-11-9
Synonyms: A-56268

Clarithromycin is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classification of clarithromycin is Macrolides.

Clarithromycin, CAS 81103-11-9
Pack Size Availability Price/USD Quantity
25 mg In stock 38.00
50 mg In stock 50.00
100 mg In stock 61.00
200 mg In stock 79.00
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Purity 99.89%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Clarithromycin is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classification of clarithromycin is Macrolides.
Targets&IC50 50S ribosome ,   MRP1
In vitro Clarithromycin suppresses this production in a dose-dependent manner in both monocytes and THP-1 cells. Clarithromycin regulates three other promoters that have either the NF-kappa B or the AP-1 binding sequences: two synthetic (pAP-1-Luc and pNF-kappa B-Luc) and one naturally occurring (ELAM-Luc). [1] Clarithromycin suppresses NF-kappaB activation induced by TNF-alpha in U-937 and Jurkat cells in a concentration-related manner. Clarithromycin inhibits NF-kappaB activation induced by TNF-alpha in U-937, Jurkat, and A549 cells and PBMC and by SEA in PBMC. Clarithromycin prevents NF-kappaB-dependent reporter gene expression in U-937 cells. [2] Clarithromycin results in a significant suppression of production of each cytokine in 71% and a significant increase in 29% of the human monocytes. [3] Clarithromycin inhibits tumor necrosis factor (TNF)-alpha-induced IL-8 gene expression in a dose- and incubation time-dependent manner. Clarithromycin represses AP-1 binding in TNF-alpha-treated BET-1A cells. Clarithromycin represses IL-8 gene transcription mainly via the AP-1 binding site in human bronchial epithelial cells. [4] Clarithromycin suppresses IL-1 beta gene expression in human nasal epithelial cells stimulated by H. influenzae endotoxin (HIE). Clarithromycin suppresses intercellular adhesion molecule-1 gene expression in nasal fibroblasts stimulated by IL-1 beta. Clarithromycin reduces DNA-binding activity of NF-kappa B in both human nasal epithelial cells and fibroblasts stimulated by HIE or IL-1 beta, respectively. [5]
Synonyms A-56268
Purity 99.89%
Molecular Weight 747.95
Formula C38H69NO13
CAS No. 81103-11-9

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 33.4 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Kikuchi T, et al. J Antimicrob Chemother, 2002, 49(5), 745-755. 2. Ichiyama T, et al. Antimicrob Agents Chemother, 2001, 45(1), 44-47. 3. Khan AA, et al. Int J Antimicrob Agents, 1999, 11(2), 121-132. 4. Abe S, et al. Am J Respir Cell Mol Biol, 2000, 22(1), 51-60. 5. Miyanohara T, et al. Laryngoscope, 2000, 110(1), 126-131.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Anti-infection Compound Library Autophagy Compound Library FDA-approved Drug Library Immunology/Inflammation Compound Library Antibiotics Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Anti-Metabolism Disease Compound Library Anti-obesity Compound Library Anti-aging Compound Library Anti-cancer Drug library Drug Repurposing Library Macrocyclic Compounds Library Antibacterial Activity Library Drug-induced Liver Injury (DILI) Compound Library Nonsteroidal Antiinflammatory Compound Library NMPA-Approved Drug Library FDA Approved & Pharmacopeial Drug Library

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