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Clarithromycin

Catalog No. T1434 CAS 81103-11-9

Synonyms: A-56268

Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classification of clarithromycin is Macrolides.

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Clarithromycin, CAS 81103-11-9

Pack Size	Availability	Price/USD
100 mg	In stock	$ 50.00
200 mg	In stock	$ 57.00
500 mg	In stock	$ 74.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 99.89%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

Clarithromycin suppresses this production in a dose-dependent manner in both monocytes and THP-1 cells. Clarithromycin regulates three other promoters that have either the NF-kappa B or the AP-1 binding sequences: two synthetic (pAP-1-Luc and pNF-kappa B-Luc) and one naturally occurring (ELAM-Luc). [1] Clarithromycin suppresses NF-kappaB activation induced by TNF-alpha in U-937 and Jurkat cells in a concentration-related manner. Clarithromycin inhibits NF-kappaB activation induced by TNF-alpha in U-937, Jurkat, and A549 cells and PBMC and by SEA in PBMC. Clarithromycin prevents NF-kappaB-dependent reporter gene expression in U-937 cells. [2] Clarithromycin results in a significant suppression of production of each cytokine in 71% and a significant increase in 29% of the human monocytes. [3] Clarithromycin inhibits tumor necrosis factor (TNF)-alpha-induced IL-8 gene expression in a dose- and incubation time-dependent manner. Clarithromycin represses AP-1 binding in TNF-alpha-treated BET-1A cells. Clarithromycin represses IL-8 gene transcription mainly via the AP-1 binding site in human bronchial epithelial cells. [4] Clarithromycin suppresses IL-1 beta gene expression in human nasal epithelial cells stimulated by H. influenzae endotoxin (HIE). Clarithromycin suppresses intercellular adhesion molecule-1 gene expression in nasal fibroblasts stimulated by IL-1 beta. Clarithromycin reduces DNA-binding activity of NF-kappa B in both human nasal epithelial cells and fibroblasts stimulated by HIE or IL-1 beta, respectively. [5]

Synonyms	A-56268
Molecular Weight	747.95
Formula	C38H69NO13
CAS No.	81103-11-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (66.85 mM)

References and Literature

1. Kikuchi T, et al. J Antimicrob Chemother, 2002, 49(5), 745-755. 2. Ichiyama T, et al. Antimicrob Agents Chemother, 2001, 45(1), 44-47. 3. Khan AA, et al. Int J Antimicrob Agents, 1999, 11(2), 121-132. 4. Abe S, et al. Am J Respir Cell Mol Biol, 2000, 22(1), 51-60. 5. Miyanohara T, et al. Laryngoscope, 2000, 110(1), 126-131.

Citations

1. Li H, Li J, Li J, et al.Carrimycin inhibits coronavirus replication by decreasing the efficiency of programmed–1 ribosomal frameshifting through directly binding to the RNA pseudoknot of viral frameshift-stimulatory element.Acta Pharmaceutica Sinica B.2024

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Drug-induced Liver Injury (DILI) Compound Library Human Metabolite Library Immunology/Inflammation Compound Library Pediatric Drug Library Anti-Metabolism Disease Compound Library

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Related compounds with same targets

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Keywords

Clarithromycin 81103-11-9 Autophagy Immunology/Inflammation Metabolism Microbiology/Virology MRP Antibacterial Antibiotic P450 ribosome CYPs A56268 CYP3A4 HERG Inhibitor potassium A-56268 autophagic current Antimicrobial flux A 56268 inhibit Cytochrome P450 Bacterial inhibitor

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