cox-2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10032	COX-2-IN-2		COX
	COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic acti...		COX
T10033	COX-2-IN-1		COX
	COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).		COX
T77618	COX-2-IN-34		COX
	COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.		COX
T62061	COX-2-IN-6		COX , Prostaglandin Receptor
	COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is u...		COX , Prostaglandin Receptor
T7207	FK 3311	FK-3311,COX-2 Inhibitor V	COX
	FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID)		COX
T0432	Diclofenac diethylamine		Apoptosis , COX
	Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).		Apoptosis , COX
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
T6S0413	Pectolinarigenin	Pectolinaringenin	Others , Lipoxygenase , COX
	1. Pectolinarigenin (Pectolinaringenin) exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity and that they may inhibit eicosanoid formation in ...		Others , Lipoxygenase , COX
T0458	Indomethacin	Indocin,Indometacine,Indomethacine,Indometacin	Phospholipase , COX , PDE , Autophagy
	Indomethacin (Indometacin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.		Phospholipase , COX , PDE , Autophagy
T6737	Zaltoprofen	CN100,Soleton	COX
	Zaltoprofen (Soleton) is a Cox-1 and Cox-2 inhibitor, which is used for the treatment of arthritis.		COX
T0196	Diclofenac	Diclofenacum,Voltaren	Apoptosis , COX
	Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of a...		Apoptosis , COX
T0448	(S)-(+)-Ibuprofen	Dexibuprofen,(S)-Ibuprofen	BCL , Thrombin , Cysteine Protease , COX , PPAR
	(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).		BCL , Thrombin , Cysteine Protease , COX , PPAR
T1555	Diclofenac sodium	GP 45840	Apoptosis , COX
	Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.		Apoptosis , COX
T6470	Diclofenac Potassium	CGP-45840B,Cataflam,Voltfast	Apoptosis , Others , COX
	Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.		Apoptosis , Others , COX
T3399	Psoralidin		Others , Estrogen/progestogen Receptor , Reactive Oxygen Species , Lipoxygenase , Gamma-secretase , Akt , COX , Antibacterial
	Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive properties.
T8356	FPL 62064		Lipoxygenase , COX
	FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase, respectively).		Lipoxygenase , COX
T22368	Metyrosine	α-Methyltyrosine	COX
	Metyrosine (α-Methyltyrosine) is an antihypertensive drug and could be used as a tyrosine hydroxylase inhibitor.Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressu...		COX
T7596	Firocoxib	ML 1785713	COX
	Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cycooxygenase-2 (COX-2) (IC50 of 0.13 μM), with anti-inflammatory for use in dogs and horses.		COX
T5S0045	Isofraxidin	6,8-Dimethoxyumbelliferone,Phytodolor	MMP , ERK , p38 MAPK , TLR , COX
	1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote...		MMP , ERK , p38 MAPK , TLR , COX
T7838	Losartan Carboxaldehyde		COX
	Losartan Carboxaldehyde is an endothelial cyclooxygenase (COX)-2 inhibitor.		COX