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Immunology/Inflammation COX Diclofenac sodium

Diclofenac sodium

Catalog No. T1555   CAS 15307-79-6
Synonyms: GP 45840

Diclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.

Diclofenac sodium, CAS 15307-79-6
Pack Size Availability Price/USD Quantity
10 mg In stock 20.00
50 mg In stock 33.00
100 mg In stock 40.00
200 mg In stock 50.00
500 mg In stock 60.00
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Purity 99.89%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Diclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
Targets&IC50 COX-1 ,   COX-2
In vitro Diclofenac inhibits Wnt/beta-catenin signaling without altering the level of beta-catenin protein and reduces the expression of beta-catenin/TCF-dependent genes. Diclofenac induces the degradation of IkappaBalpha, which increases free nuclear factor kappaB (NF-kappaB) in colon cancer cells. [1] Diclofenac suppresses both fast tetrodotoxin-sensitive (TTX-S) and the slow tetrodotoxin-resistant (TTX-R) sodium currents in a dose-dependent manner. Diclofenac produces shifts of the steady-state inactivation curves in the hyperpolarizing direction in both types of sodium currents in a dose-dependent manner. Diclofenac may bind to sodium channels with a greater affinity when they are in the inactivated state than when they are in the resting state. [2] Diclofenac results in a severe accumulation of protein in the tubular cells (so called hyaline droplet degeneration), macrophage infiltration and structural alterations (dilation, vesiculation) of the endoplasmic reticulum (ER) in the proximal and distal renal tubules of kidney. Diclofenac also results in shortening of podocytes and their retraction from the basal lamina, a thickening of the basal lamina, the formation of desmosomes, and necrosis of endothelial cells in the renal corpuscles of kidney. [3]
In vivo Diclofenac (0.01 to 0.2 mM) stimulates state-4 respiration and slightly inhibits state 3 in rats, decreasing the respiratory control ratio, while the membrane potential is decreased or collapsed (depending on the drug concentration). [4]
Synonyms GP 45840
Purity 99.89%
Molecular Weight 318.13
Formula C14H10Cl2NNaO2
CAS No. 15307-79-6

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 31.8 mg/mL (100 mM)

water: 15.9 mg/mL (50 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Kirchheiner J, et al. Br J Clin Pharmacol. 2003 Jan;55(1):51-61.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Anti-cancer Compound Library Apoptosis Compound Library Ion Channel Inhibitor Library FDA-approved Drug Library Immunology/Inflammation Compound Library Bioactive Lipid Compound Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Anti-Cardiovascular Disease Compound Library CNS-Penetrant Compound Library Anti-cancer Drug library HIF-1 Signaling Pathway Compound Library Nonsteroidal Antiinflammatory Compound Library NMPA-Approved Drug Library FDA Approved & Pharmacopeial Drug Library Anti-Breast Cancer Compound Library

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