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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T73224 | AMPK-IN-1 | ||
AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM. It induces phosphorylation of eEF2 independent of the mTORC1 pathway. | |||
TN6751 | 1-HEXACOSANOL | NPC1L1 , AMPK | |
Hexacosanol activates AMPK and hepatic autophagy and inhibits SREBP2, resulting in hypocholesterolemic activities and improvement of hepatic steatosis. | |||
T73350 | BAY-3827 | Acyltransferase , AMPK | |
BAY-3827 is a potent and selective AMPK inhibitor with potential antitumor activity, showing antiproliferative activity in an androgen-dependent prostate cancer model. BAY-3827 inhibits the phosphorylation of acetyl CoA ... | |||
T8532 | IM156 | OXPHOS | |
IM156 (HL156A; HL271 acetate) is a chemical derivative of Metformin. IM156 is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in anima... | |||
T5S2178 | Fargesin | (+/-)-Fargesin | Adrenergic Receptor |
1. Fargesin ((+/-)-Fargesin) as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats. 2. Fargesin improves dyslipidemia and hyperglycemia by activating... | |||
T3S0195 | Nootkatone | AMPK | |
1. Nootkatone can provide effective tick control. 2. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. 3. Nootkatone can prevent obesity and improve physical performance through AMPK activa... | |||
T6S1683 | Demethoxycurcumin | Curcumin II,Desmethoxycurcumin,Monodemethoxycurcumin | Apoptosis , Antioxidant , Antibacterial , Autophagy |
1. Demethoxycurcumin (Desmethoxycurcumin) has antioxidant activity. 2. Demethoxycurcumin has anti-inflammatory activity. 3. Demethoxycurcumin has anti-proliferative activity. 4. Demethoxycurcumin has anti-acanthamoebic e... | |||
T16342 | KL1333 | NQO1 activator 1 | NADPH , Mitochondrial Metabolism |
KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 ... | |||
T4S0878 | Prunetin | Prunusetin | ERK , Dehydrogenase , NF-κB |
1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit... | |||
T4S0800 | Demethyleneberberine | P450 , NOS , NF-κB , HIF , AMPK | |
Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either in vitro or in vivo.Demethyleneberberine suppresses CYP2E1,... | |||
T6S1784 | Brazilin | Natural Red 24,Braziletto,Brasilin,Superbresiline | Apoptosis , Others , AMPK , Autophagy |
1. Brazilin (Braziletto) exhibits anti-hepatotoxic, antiplatelet effects. 2. Brazilin has cancer preventive effect, may inhibit T24 cell growth and trigger cell death through a c-Fos-mediated and tumor cell specific sign... | |||
T83127 | AMPK activator 13 | AMPK | |
AMPK Activator 13 is a potent activator of the AMPK pathway, effectively inhibiting mitotic clonal expansion in 3T3-L1 cells and enhancing mitochondrial oxygen consumption rates. This compound is utilized in the study of... | |||
T83125 | AMPK-α1β1γ1 activator 1 | AMPK | |
AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1 isoforms of human AMPK with an EC50 of 38.1 nM through direct bindi... | |||
T79649 | CB1R/AMPK modulator 1 | Cannabinoid Receptor | |
Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R. This compound activates AMPK and has been shown to decrease food intake and body weight, in addition to enhancin... | |||
T36535 | SEC | ||
SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2]. | |||
T78196 | SIK2-IN-1 | ||
SIK2-IN-1 (compound 8g) is a potent inhibitor of SIK2 with selectivity over other AMPK-family kinases, demonstrating favorable ADMET profiles in vitro and robust cellular activities [1]. | |||
T70296 | JJO-1 | ||
JJO-1 is a bi-quinoline that allosterically activates all AMPK αβγ isoforms in vitro except complexes containing the γ3 subunit. JJO-1 does not directly activate the autoinhibited α subunit kinase domain and differs amon... | |||
T79226 | AMPK activator 11 | Mitochondrial Metabolism | |
AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative... | |||
TL0014 | Pinusolide | ERK , p38 MAPK , Calcium Channel , Lipoxygenase , PAFR , Caspase , JNK , AMPK | |
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinus... | |||
T79949 | Foenumoside B | PPAR | |
Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotes lipolysis, shifting lipid metabolism. This compound is utilized... |